The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Characterization of an autoregulated response element in the mouse retinoic acid receptor type beta gene.
Open accessAbstract
A sequence that confers transcriptional responsiveness to retinoic acid was identified in the promoter of the mouse retinoic acid receptor (RAR) beta gene. This response element consists of a direct repeat of the sequence GTTCAC, separated by five nucleotides. Direct binding of the RAR to this sequence was demonstrated by gel retardation and immunoprecipitation assays. This element conferred retinoic acid responsiveness on heterologous promoters via all three subtypes of RAR yet failed to support transcriptional activation by the thyroid hormone, estrogen, glucocorticoid, or vitamin D receptors. Surprisingly, a high level of retinoic acid-dependent activation was seen in the absence of transfected RAR in 10 of 10 vertebrate cell lines, many functionally characterized previously as lacking endogenous receptor. This demonstrates an unusually high sensitivity of the retinoic acid response element to low levels of receptor and suggests expression of RAR in a wide variety of tissue types.
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Cites
A human retinoic acid receptor which belongs to the family of nuclear receptors
Petkovich, M., Brand, N. J., Krust, A., & Chambon, P. (1987) · Nature · doi:10.1038/330444a0 · Cited by 2,214
Identification of a receptor for the morphogen retinoic acid
Giguere, V., Ong, E. S., Segui, P., & Evans, R. M. (1987) · Nature · doi:10.1038/330624a0 · Cited by 1,965
Self-citation
Cited by
LXR, a nuclear receptor that defines a distinct retinoid response pathway.
Willy, P. J., Umesono, K., Ong, E. S., Evans, R. M., Heyman, R. A., & Mangelsdorf, D. J. (1995) · Genes & Development · doi:10.1101/gad.9.9.1033 · Cited by 1,123
Self-citationSmith, M. A., Parkinson, D. R., Cheson, B. D., & Friedman, M. A. (1992) · Journal of Clinical Oncology · doi:10.1200/jco.1992.10.5.839 · Cited by 486
Regulation of retinoid signalling by receptor polarity and allosteric control of ligand binding
Kurokawa, R., DiRenzo, J., Boehm, M., Sugarman, J., Gloss, B., Rosenfeld, M. G., Heyman, R. A., & Glass, C. K. (1994) · Nature · doi:10.1038/371528a0 · Cited by 429
Zelent, A., Mendelsohn, C., Kastner, P., Krust, A., Garnier, J. M., Ruffenach, F., Leroy, P., & Chambon, P. (1991) · The EMBO Journal · doi:10.1002/j.1460-2075.1991.tb07922.x · Cited by 379
Inhibition of nuclear hormone receptor activity by calreticulin
Dedhar, S., Rennie, P. S., Shago, M., Hagesteijn, C.-Y. L., Yang, H., Filmus, J., Hawley, R. G., Bruchovsky, N., Cheng, H., Matusik, R. J., et al. (1994) · Nature · doi:10.1038/367480a0 · Cited by 375
Metadata
- Authors
- Sucov, H. M., Murakami, K. K., & Evans, R. M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1990-07
- Volume
- 87
- Issue
- 14
- Pages
- 5392-5396
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2002529271
- Cited by
- 467
- References
- 2
- FWCI
- 19.45
- Type
- journal article
- Language
- en
- Open access
- green
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- Sucov, H. M., Murakami, K. K., & Evans, R. M. (1990). Characterization of an autoregulated response element in the mouse retinoic acid receptor type beta gene. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.87.14.5392
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