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Mismatch-specific thymine DNA glycosylase and DNA polymerase beta mediate the correction of G.T mispairs in nuclear extracts from human cells.
Open accessAbstract
To avoid the mutagenic effect of spontaneous hydrolytic deamination of 5-methylcytosine, G.T mispairs, arising in DNA as a result of this process, should always be corrected to G.C pairs. We describe here the identification of a DNA glycosylase activity present in nuclear extracts from HeLa cells, which removes the mispaired thymine to generate an apyrimidinic (AP) site opposite the guanine. We further show, using a specific antibody and inhibitors, that the single nucleotide gap, created upon processing of the AP site, is filled in by DNA polymerase beta. This finding substantiates the proposed role of this enzyme in short-patch DNA repair.
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Cited by
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Matsumoto, Y., & Kim, K. (1995) · Science · doi:10.1126/science.7624801 · Cited by 683
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Inoue, N., Dong, R., Hirata, R. K., & Russell, D. W. (2001) · Molecular Therapy · doi:10.1006/mthe.2001.0283 · Cited by 62
Metadata
- Authors
- Wiebauer, K., & Jiricny, J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1990-08
- Volume
- 87
- Issue
- 15
- Pages
- 5842-5845
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2086829507
- Cited by
- 252
- References
- 0
- FWCI
- 7.29
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Mismatch-specific thymine DNA glycosylase and DNA polymerase beta mediate the correction of G.T mispairs in nuclear extracts from human cells. https://app.cochat.ai/papers/10.1073/pnas.87.15.5842
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- Wiebauer, K., & Jiricny, J. (1990). Mismatch-specific thymine DNA glycosylase and DNA polymerase beta mediate the correction of G.T mispairs in nuclear extracts from human cells. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.87.15.5842
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