The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Opioids from immunocytes interact with receptors on sensory nerves to inhibit nociception in inflammation.
Open accessAbstract
Exogenous opioids can produce localized opioid receptor-mediated antinociception in peripheral inflamed tissue. Previous studies show that activation of endogenous opioids by a cold water swim in rats with hind paw inflammation results in a similar local antinociceptive effect but suggest that pituitary-adrenal opioid pools are not directly involved in producing this effect. Here we show increased amounts of opioid peptides in immune cells infiltrating the inflamed tissue. Furthermore, we demonstrate immunoreactive opioid receptors on peripheral terminals of sensory neurons. The local administration of antibodies against opioid peptides or receptors or systemic pretreatment with the immunosuppressant cyclosporine blocks cold water swim-induced antinociception. These findings suggest that antinociception in inflammation can be brought about by endogenous opioids from immune cells interacting with opioid receptors on peripheral sensory nerves.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
β-Endorphin and Adrenocorticotropin Are Selected Concomitantly by the Pituitary Gland
Guillemin, R., Vargo, T., Rossier, J., Minick, S., Ling, N., Rivier, C., Vale, W., & Bloom, F. (1977) · Science · doi:10.1126/science.197601 · Cited by 1,419
Cited by
Neuroimmune Interactions: From the Brain to the Immune System and Vice Versa
Dantzer, R. (2018) · Physiological Reviews · doi:10.1152/physrev.00039.2016 · Cited by 1,073
Attacking pain at its source: new perspectives on opioids
Stein, C., Schäfer, M., & Machelska, H. (2003) · Nature Medicine · doi:10.1038/nm908 · Cited by 608
Self-citationIbrahim, M. M., Porreca, F., Lai, J., Albrecht, P. J., Rice, F. L., Khodorova, A., Davar, G., Makriyannis, A., Vanderah, T. W., Mata, H. P., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409888102 · Cited by 521
Dynorphin activates quorum sensing quinolone signaling in Pseudomonas aeruginosa
Zaborina, O., Lepine, F., Xiao, G., Valuckaite, V., Chen, Y., Li, T., Ciancio, M., Zaborin, A., Petroff, E., Turner, J. R., et al. (2007) · PLoS Pathogens · doi:10.1371/journal.ppat.0030035 · Cited by 207
Metadata
- Authors
- Stein, C., Hassan, A. H., Przewłocki, R., Gramsch, C., Peter, K., & Herz, A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1990-08
- Volume
- 87
- Issue
- 15
- Pages
- 5935-5939
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2059730682
- Cited by
- 587
- References
- 1
- FWCI
- 9.97
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Opioids from immunocytes interact with receptors on sensory nerves to inhibit nociception in inflammation. https://app.cochat.ai/papers/10.1073/pnas.87.15.5935
- The paper
- Stein, C., Hassan, A. H., Przewłocki, R., Gramsch, C., Peter, K., & Herz, A. (1990). Opioids from immunocytes interact with receptors on sensory nerves to inhibit nociception in inflammation. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.87.15.5935
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
