The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Preferential infection of CD4+ memory T cells by human immunodeficiency virus type 1: evidence for a role in the selective T-cell functional defects observed in infected individuals.
Open accessAbstract
CD4+ T cells of patients with AIDS exhibit a qualitative defect in their ability to respond to soluble antigen while their responses to mitogens remain normal. CD4+ T cells can be broadly divided phenotypically into "naive" [CD45RA+ (2H4+)] and "memory" [CD29+ (4B4+) or CD45RO+ (UCHL1+)] cell subpopulations, which represent distinct maturation stages. To determine the human immunodeficiency virus type 1 (HIV-1) infectability of memory and naive CD4+ T-cell subsets in vitro and to determine the in vivo preference of HIV-1 in these subpopulations, we obtained highly purified CD4+ T-cell subsets from normal and HIV-1-infected individuals and studied them by viral cultivation, quantitative polymerase chain reaction, and functional assays. Polymerase chain reaction studies demonstrated that the memory cell subset of CD4+ T cells is preferentially infected (4- to 10-fold more than naive T cells) by HIV-1 in vitro, and these memory cells are the principal reservoir for HIV-1 within CD4+ T cells obtained from infected individuals. Functional abnormalities attributable to CD4+ T cells in HIV-infected individuals (failure to respond in vitro to soluble antigen or to anti-CD3 monoclonal antibodies) were shown to reside primarily within these memory cells. Thus, the present study suggests that the selective functional defects present in the memory CD4+ T-cell subset of HIV-infected individuals may be a direct result of the preferential infection and consequently greater viral burden within these cells.
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Citations
Cites
T-lymphocyte T4 molecule behaves as the receptor for human retrovirus LAV
Klatzmann, D., Champagne, E., Chamaret, S., Gruest, J., Guetard, D., Hercend, T., Gluckman, J.-C., & Montagnier, L. (1984) · Nature · doi:10.1038/312767a0 · Cited by 2,436
The Human Immunodeficiency Virus: Infectivity and Mechanisms of Pathogenesis
Fauci, A. S. (1988) · Science · doi:10.1126/science.3277274 · Cited by 1,486
Self-citationSelective Tropism of Lymphadenopathy Associated Virus (LAV) for Helper-Inducer T Lymphocytes
Klatzmann, D., Barré-Sinoussi, F., Nugeyre, M. T., Danguet, C., Vilmer, E., Griscelli, C., Brun-Veziret, F., Rouzioux, C., Gluckman, J. C., Chermann, J.-C., et al. (1984) · Science · doi:10.1126/science.6328660 · Cited by 969
Loss of CD45R and gain of UCHL1 reactivity is a feature of primed T cells.
Akbar, A. N., Terry, L., Timms, A., Beverley, P. C., & Janossy, G. (1988) · The Journal of Immunology · doi:10.4049/jimmunol.140.7.2171 · Cited by 921
Sanders, M. E., Makgoba, M. W., Sharrow, S. O., Stephany, D., Springer, T. A., Young, H. A., & Shaw, S. (1988) · The Journal of Immunology · doi:10.4049/jimmunol.140.5.1401 · Cited by 906
The isolation and characterization of the human suppressor inducer T cell subset.
Morimoto, C., Letvin, N. L., Distaso, J. A., Aldrich, W. R., & Schlossman, S. F. (1985) · The Journal of Immunology · doi:10.4049/jimmunol.134.3.1508 · Cited by 848
HIV-specific cytotoxic T lymphocytes in seropositive individuals
Walker, B. D., Chakrabarti, S., Moss, B., Paradis, T. J., Flynn, T., Durno, A. G., Blumberg, R. S., Kaplan, J. C., Hirsch, M. S., & Schooley, R. T. (1987) · Nature · doi:10.1038/328345a0 · Cited by 784
Human naive and memory T cells
Sanders, M. E., Makgoba, M. W., & Shaw, S. (1988) · Immunology Today · doi:10.1016/0167-5699(88)91212-1 · Cited by 781
Lane, H. C., Depper, J. M., Greene, W. C., Whalen, G., Waldmann, T. A., & Fauci, A. S. (1985) · New England Journal of Medicine · doi:10.1056/nejm198507113130204 · Cited by 728
Self-citationThe Reservoir for HIV-1 in Human Peripheral Blood Is a T Cell That Maintains Expression of CD4
Schnittman, S. M., Psallidopoulos, M. C., Lane, H. C., Thompson, L., Baseler, M., Massari, F., Fox, C. H., Salzman, N. P., & Fauci, A. S. (1989) · Science · doi:10.1126/science.2665081 · Cited by 714
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Cited by
Changes in thymic function with age and during the treatment of HIV infection
Douek, D. C., McFarland, R. D., Keiser, P. H., Gage, E. A., Massey, J. M., Haynes, B. F., Polis, M. A., Haase, A. T., Feinberg, M. B., Sullivan#, J. L., et al. (1998) · Nature · doi:10.1038/25374 · Cited by 1,893
Seventeen-colour flow cytometry: unravelling the immune system
Perfetto, S. P., Chattopadhyay, P. K., & Roederer, M. (2004) · Nature Reviews Immunology · doi:10.1038/nri1416 · Cited by 1,019
Weiss, R. A. (1993) · Science · doi:10.1126/science.8493571 · Cited by 680
Perreau, M., Savoye, A.-L., De Crignis, E., Corpataux, J.-M., Cubas, R., Haddad, E. K., De Leval, L., Graziosi, C., & Pantaleo, G. (2013) · Journal of Experimental Medicine · doi:10.1084/jem.20121932 · Cited by 630
Pope, M., Betjes, M. G. H., Romani, N., Hirmand, H., Cameron, P. U., Hoffman, L., Gezelter, S., Schuler, G., & Steinman, R. M. (1994) · Cell · doi:10.1016/0092-8674(94)90418-9 · Cited by 494
Metadata
- Authors
- Schnittman, S. M., Lane, H. C., Greenhouse, J., Justement, J. S., Baseler, M., & Fauci, A. S.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1990-08
- Volume
- 87
- Issue
- 16
- Pages
- 6058-6062
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2093044736
- Cited by
- 425
- References
- 28
- FWCI
- 7.70
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Preferential infection of CD4+ memory T cells by human immunodeficiency virus type 1: evidence for a role in the selective T-cell functional defects observed in infected individuals. https://app.cochat.ai/papers/10.1073/pnas.87.16.6058
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- Schnittman, S. M., Lane, H. C., Greenhouse, J., Justement, J. S., Baseler, M., & Fauci, A. S. (1990). Preferential infection of CD4+ memory T cells by human immunodeficiency virus type 1: evidence for a role in the selective T-cell functional defects observed in infected individuals. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.87.16.6058
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
