The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Posttranslational modification of class III beta-tubulin.
Open accessAbstract
The charge heterogeneity of class III beta-tubulin (beta III) during neural development was analyzed by high-resolution isoelectric focusing/two-dimensional polyacrylamide gel electrophoresis in combination with site-specific proteolytic digestion and immunological detection. The number of beta III isoforms (charge variants) gradually increases from one in embryonic brain to seven in adult brain. All of the charge heterogeneity is due to posttranslationally modified sites located within the extreme C-terminal region of the beta III polypeptide. One beta III isoform is present in testis, the only other tissue in which this isotype is expressed. The testis beta III isoform cofocuses with the earliest-appearing embryonic brain beta III charge variant. Our results indicate that the posttranslational modifications of beta III are developmentally regulated, occur at more than one site, and are neuron-specific. The location of these modifications within the extreme C-terminal domain suggests that their function is to modulate the interaction of tubulin with microtubule-associated proteins.
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Vallee, R. B. (1982) · The Journal of cell biology · doi:10.1083/jcb.92.2.435 · Cited by 551
Cited by
Borchelt, D. R., Lee, M. K., Slunt, H. S., Guarnieri, M., Xu, Z. S., Wong, P. C., Brown, R. H., Price, D. L., Sisodia, S. S., & Cleveland, D. W. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.17.8292 · Cited by 621
Self-citationIn vitro neurogenesis by progenitor cells isolated from the adult human hippocampus
Roy, N. S., Wang, S., Jiang, L., Kang, J., Benraiss, A., Harrison-Restelli, C., Fraser, R. A. R., Couldwell, W. T., Kawaguchi, A., Okano, H., et al. (2000) · Nature Medicine · doi:10.1038/73119 · Cited by 559
Benraiss, A., Chmielnicki, E., Lerner, K., Roh, D., & Goldman, S. A. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-17-06718.2001 · Cited by 540
Initial tract formation in the mouse brain
Easter, S., Ross, L., & Frankfurter, A. (1993) · The Journal of Neuroscience · doi:10.1523/jneurosci.13-01-00285.1993 · Cited by 391
Self-citationIsolation of Multipotent Neural Precursors Residing in the Cortex of the Adult Human Brain
Arsenijevic, Y., Villemure, J.-G., Brunet, J.-F., Bloch, J. J., Déglon, N., Kostic, C., Zurn, A., & Aebischer, P. (2001) · Experimental Neurology · doi:10.1006/exnr.2001.7691 · Cited by 310
Metadata
- Authors
- Lee, M. K., Rebhun, L. I., & Frankfurter, A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1990-09
- Volume
- 87
- Issue
- 18
- Pages
- 7195-7199
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1998148816
- Cited by
- 202
- References
- 1
- FWCI
- 2.33
- Type
- journal article
- Language
- en
- Open access
- green
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- Lee, M. K., Rebhun, L. I., & Frankfurter, A. (1990). Posttranslational modification of class III beta-tubulin. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.87.18.7195
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