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An ancient, highly conserved family of cysteine-rich protein domains revealed by cloning type I and type II murine macrophage scavenger receptors.
Open accessAbstract
Scavenger receptors have been implicated in the development of atherosclerosis and other macrophage-associated functions. The bovine type I and type II scavenger receptors are multidomain transmembrane proteins that differ only by the presence in the type I receptor of an additional, extracellular cysteine-rich C-terminal domain. The isolation of type I and type II receptor cDNAs from a murine macrophage cell line, P388D1, establishes the presence of mRNAs encoding both receptor types in a single cell. Their sequences are highly similar to the bovine cDNAs. Receptor type-specific cDNA probes map to a common locus on murine chromosomes 8, suggesting that a single gene encodes both mRNAs. The type I-specific scavenger receptor cysteine-rich (SRCR) domain helps define a previously unrecognized family of remarkably well-conserved domains. Highly homologous SRCR domains (one, three, or four per polypeptide chain) are found in diverse secreted and cell-surface proteins from humans (e.g., CD5, complement factor I), mice (Ly-1), and sea urchins (speract receptor).
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Cites
Needleman, S. B., & Wunsch, C. D. (1970) · Journal of Molecular Biology · doi:10.1016/0022-2836(70)90057-4 · Cited by 11,288
Cited by
A Null Mutation in Murine CD36 Reveals an Important Role in Fatty Acid and Lipoprotein Metabolism
Febbraio, M., Abumrad, N. A., Hajjar, D. P., Sharma, K., Cheng, W., Pearce, S. F. A., & Silverstein, R. L. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.27.19055 · Cited by 769
Chinetti, G., Gbaguidi, F. G., Griglio, S., Mallat, Z., Antonucci, M., Poulain, P., Chapman, J., Fruchart, J.-C., Tedgui, A., Najib-Fruchart, J., et al. (2000) · Circulation · doi:10.1161/01.cir.101.20.2411 · Cited by 428
Doens, D., & Fernández, P. L. (2014) · Journal of Neuroinflammation · doi:10.1186/1742-2094-11-48 · Cited by 348
A new macrophage differentiation antigen which is a member of the scavenger receptor superfamily
Law, S. K. A., Micklem, K. J., Shaw, J. M., Zhang, X., Dong, Y., Willis, A. C., & Mason, D. Y. (1993) · European Journal of Immunology · doi:10.1002/eji.1830230940 · Cited by 275
Metadata
- Authors
- Freeman, M., Ashkenas, J., Rees, D. J., Kingsley, D. M., Copeland, N. G., Jenkins, N. A., & Krieger, M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1990-11
- Volume
- 87
- Issue
- 22
- Pages
- 8810-8814
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2064244952
- Cited by
- 309
- References
- 1
- FWCI
- 21.63
- Type
- journal article
- Language
- en
- Open access
- green
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- Freeman, M., Ashkenas, J., Rees, D. J., Kingsley, D. M., Copeland, N. G., Jenkins, N. A., & Krieger, M. (1990). An ancient, highly conserved family of cysteine-rich protein domains revealed by cloning type I and type II murine macrophage scavenger receptors. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.87.22.8810
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