The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Hemoglobin degradation in the malaria parasite Plasmodium falciparum: an ordered process in a unique organelle.
Open accessAbstract
The malaria parasite Plasmodium falciparum uses host erythrocyte hemoglobin as a major nutrient source. We report the purification of P. falciparum digestive vacuoles and characterization of the degradative process therein. Vacuoles were isolated by a combination of differential centrifugation and density gradient separation. The pure vacuoles were capable of degrading hemoglobin to small fragments with a pH optimum of 5-5.5. Proteolysis in the vacuoles appears to be an ordered process, requiring an aspartic protease to clip intact hemoglobin before other proteolytic activities can function efficiently. The vacuoles do not contain other hydrolases commonly found in lysosomes and therefore appear to be unique proteolytic organelles designed specifically to degrade hemoglobin.
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Citations
Cites
A malarial cysteine proteinase is necessary for hemoglobin degradation by Plasmodium falciparum
Rosenthal, P. J., McKerrow, J. H., Aikawa, M., Nagasawa, H., & Leech, J. H. (1988) · Journal of Clinical Investigation · doi:10.1172/jci113766 · Cited by 331
Cited by
Fidock, D. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)00084-8 · Cited by 1,456
Iron-dependent free radical generation from the antimalarial agent artemisinin (qinghaosu)
Meshnick, S. R., Yang, Y. Z., Lima, V, Kuypers, F., Kamchonwongpaisan, S., & Yuthavong, Y. (1993) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.37.5.1108 · Cited by 327
Molecular characterization and inhibition of a Plasmodium falciparum aspartic hemoglobinase.
Francis, S. E., Gluzman, I. Y., Oksman, A., Knickerbocker, A., Mueller, R., Bryant, M. L., Sherman, D. R., Russell, D. G., & Goldberg, D. E. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06263.x · Cited by 277
Self-citationThe Redox Activity of Hemoglobins: From Physiologic Functions to Pathologic Mechanisms
Reeder, B. J. (2010) · Antioxidants & Redox Signaling · doi:10.1089/ars.2009.2974 · Cited by 189
A Multi-enzyme Cascade of Hemoglobin Proteolysis in the Intestine of Blood-feeding Hookworms
Williamson, A. L., Lecchi, P., Turk, B. E., Choe, Y., Hotez, P. J., McKerrow, J. H., Cantley, L. C., Sajid, M., Craik, C. S., & Loukas, A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m405842200 · Cited by 181
Metadata
- Authors
- Goldberg, D. E., Slater, A. F., Cerami, A., & Henderson, G. B.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1990-04
- Volume
- 87
- Issue
- 8
- Pages
- 2931-2935
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2090632234
- Cited by
- 485
- References
- 1
- FWCI
- 12.17
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Hemoglobin degradation in the malaria parasite Plasmodium falciparum: an ordered process in a unique organelle. https://app.cochat.ai/papers/10.1073/pnas.87.8.2931
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- Goldberg, D. E., Slater, A. F., Cerami, A., & Henderson, G. B. (1990). Hemoglobin degradation in the malaria parasite Plasmodium falciparum: an ordered process in a unique organelle. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.87.8.2931
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
