Excitatory amino acid uptake and N-methyl-D-aspartate-mediated secretion in a neural cell line
Abstract
A functional N-methyl-D-aspartate (NMDA) receptor has been identified on HT-4 cells, a clonal neural cell line, in which glutamate activates the receptor to elicit neurotransmitter secretion. Specific inhibitors of the NMDA receptor block glutamate-mediated secretion, and the characteristics of NMDA-mediated secretion parallel the reported properties of the NMDA receptor. Excitatory amino acid secretion can be elicited by potassium-evoked depolarization and is not the simple reversal of the uptake system. 2-Amino-4-phosphonobutyrate (APB) inhibits depolarization-induced secretion of excitatory amino acids but has no effect on excitatory amino acid uptake, suggesting that the APB binding protein in the brain represents a component involved in the secretion of excitatory amino acids.
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HT22 cells are immortalized primary mouse hippocampal neuronal cells, derived from parent HT4 cells.
“HT22 cells are immortalized primary mouse hippocampal neuronal cells, derived from parent HT4 cells [22,24].”
From Shared and distinct microRNA profiles between HT22, N2A and SH-SY5Y cell lines and primary mouse hippocampal neurons (2025) · cites this paper as [24]
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- [8]McFadden, P. N. & Koshland, D. È., Jr. (1990) Proc. Natl. Acad. Sci. USA 87, 2031–2035.
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Narayanan, U., Nalavadi, V., Nakamoto, M., Pallas, D. C., Ceman, S., Bassell, G. J., & Warren, S. T. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.2969-07.2007 · Cited by 228 · see citing works
Murphy, R., Villegas-Salmerón, J., Sanz-Rodriguez, A., Engel, T., Mooney, C., Henshall, D. C., & Jimenez-Mateos, E. M. (2025) · PLOS One · doi:10.1371/journal.pone.0326401 · Cited by 3 · see citing works
- Authors
- Morimoto, B. H., & Koshland, D. E.
- Affiliations
- Department of Molecular and Cellular Biology, University of California, Berkeley 94720.
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1990-05
- Volume
- 87
- Issue
- 9
- Pages
- 3518-3521
- ISSN
- 0027-8424
- 1091-6490
- Cited by
- 36
- References
- 0
- Language
- en
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