The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
A link between double-strand break-related repair and V(D)J recombination: the scid mutation.
Open accessAbstract
We show here that mammalian site-specific recombination and DNA-repair pathways share a common factor. The effects of DNA-damaging agents on cell lines derived from mice homozygous for the scid (severe combined immune deficiency) mutation were studied. Surprisingly, all scid cell lines exhibited a profound hypersensitivity to DNA-damaging agents that caused double-strand breaks (x-irradiation and bleomycin) but not to other chemicals that caused single-strand breaks or cross-links. Neutral filter elution assays demonstrated that the x-irradiation hypersensitivity could be correlated with a deficiency in repairing double-strand breaks. These data suggest that the scid gene product is involved in two pathways: DNA repair of random double-strand breaks and the site-specific and lymphoid-restricted variable-(diversity)-joining [V(D)J] DNA rearrangement process. We propose that the scid gene product performs a similar function in both pathways and may be a ubiquitous protein.
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Cites
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A severe combined immunodeficiency mutation in the mouse
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Rearrangement of antigen receptor genes is defective in mice with severe combined immune deficiency
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The scid mutation in mice causes a general defect in DNA repair
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Deoxyribonucleic acid repair in the yeast Saccharomyces cerevisiae
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X-ray sensitive mutants of Chinese hamster ovary cells defective in double-strand break rejoining
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Evidence of functional lymphocytes in some (leaky) scid mice.
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Cited by
RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement
Shinkai, Y. (1992) · Cell · doi:10.1016/0092-8674(92)90029-c · Cited by 2,150
Ma, Y., Pannicke, U., Schwarz, K., & Lieber, M. R. (2002) · Cell · doi:10.1016/s0092-8674(02)00671-2 · Cited by 1,166
Moshous, D., Callebaut, I., de Chasseval, R., Corneo, B., Cavazzana-Calvo, M., Le Deist, F., Tezcan, I., Sanal, O., Bertrand, Y., Philippe, N., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00309-9 · Cited by 912
V(D)J Recombination: Molecular Biology and Regulation
Schatz, D. G., Oettinger, M. A., & Schlissel, M. S. (1992) · Annual Review of Immunology · doi:10.1146/annurev.iy.10.040192.002043 · Cited by 466
Self-citationLi, Z., Otevrel, T., Gao, Y., Cheng, H.-L., Seed, B., Stamato, T. D., Taccioli, G. E., & Alt, F. W. (1995) · Cell · doi:10.1016/0092-8674(95)90135-3 · Cited by 458
Metadata
- Authors
- Hendrickson, E. A., Qin, X. Q., Bump, E. A., Schatz, D. G., Oettinger, M., & Weaver, D. T.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1991-05-15
- Volume
- 88
- Issue
- 10
- Pages
- 4061-4065
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2165579893
- Cited by
- 286
- References
- 25
- FWCI
- 9.39
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: A link between double-strand break-related repair and V(D)J recombination: the scid mutation. https://app.cochat.ai/papers/10.1073/pnas.88.10.4061
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- Hendrickson, E. A., Qin, X. Q., Bump, E. A., Schatz, D. G., Oettinger, M., & Weaver, D. T. (1991). A link between double-strand break-related repair and V(D)J recombination: the scid mutation. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.88.10.4061
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
