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Cited by 78Visual perception and processing mechanismsNeuroscience and Neuropharmacology ResearchFace Recognition and Perception

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Single-unit and 2-deoxyglucose studies of side inhibition in macaque striate cortex.

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Born, R T, Tootell, R B·1991·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.88.16.7071PMC PMC52235
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Abstract

In the course of studies to map spatial frequency tuning of neurons in layers 2 and 3 of macaque striate cortex, we found that a high proportion (70%) of cells in the interblob regions responded poorly to full-field gratings, compared with responses to single bars, edges, or delimited gratings. This was most often due to side inhibition, in which increasing the number of cycles of a grating placed within the cell's receptive field causes progressive inhibition of response. Quantitative receptive-field mappings showed, however, that the inhibition can occur within the region activated by a bar, as well as beyond it. The inhibition appears to be orientation-selective, in that a surround grating was more effective at inhibiting the response to a center grating patch if it was of similar orientation. 2-Deoxyglucose experiments confirmed that side inhibition is very widespread in the interblobs of layers 2 and 3 and suggested that it is reduced or lacking in layers 4A through 6. Since layers 2 and 3 of striate cortex are the major source of cortical projections to area V2 and beyond, the prevalence of side stopping in these laminae has implications for theories of cortical visual function. Side-stopped interblob cells may be acting as "contour-pass filters" that filter out redundant information in textured or noisy surfaces, focusing subsequent form processing on contrasts corresponding to object boundaries.

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  • Receptive field size of neurons increases dramatically along successive visual areas in both dorsal and ventral streams.

    “The size of the receptive fields of neurons increases dramatically as one traverses successive visual areas along the two visual streams”

    From Hierarchical Bayesian inference in the visual cortex (2003) · cites this paper as [42]

    The available Abstract describes receptive-field mapping and side inhibition in macaque striate cortex, but does not compare receptive-field sizes across successive visual areas. Searches for dorsal and ventral streams and for increasing field size found only the Abstract and references; the article body is not present in the passages returned from our copy. (LLM, conf=0.70)

    Experimental — accuracy not yet measured

  • Representations in the early visual areas (LGN, V1, and V2) are precise in both space and feature domains because of their small receptive fields arranged in retinotopic coordinates.

    “Representations in the early visual areas (LGN, V1, and V2) are precise in both space and feature domains because of their small receptive fields arranged in retinotopic coordinates. 42”

    From Hierarchical Bayesian inference in the visual cortex (2003) · cites this paper as [42]

    The indexed Abstract (page not given) describes receptive-field mapping and orientation-selective inhibition in macaque striate cortex, and mentions projections to V2. It does not address whether LGN, V1, and V2 have precise spatial and feature representations because of small, retinotopically arranged receptive fields. Searches for retinotopic coordinates and LGN yielded no passage establishing that claim. (LLM, conf=0.72)

    Experimental — accuracy not yet measured

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Research works printed but not linked: 25

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Metadata

Authors
Born, R. T., & Tootell, R. B.
Affiliations
Harvard University (US)
ORCID
Born, R T
Venue
Proceedings of the National Academy of Sciences
Publisher
National Academy of Sciences
Published
1991-08-15
Volume
88
Issue
16
Pages
7071-7075
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.88.16.7071
PMC
PMC52235
OpenAlex
W2040500739
Cited by
78
References
0
Citations by year
2026: 2 · 2024: 1 · 2022: 1 · 2018: 1 · 2017: 1 · 2016: 2 · 2015: 1 · 2014: 1
FWCI
2.34
Type
journal article
Language
en
Open access
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (2r01ey007980-08a2)
  • National Institute of Mental Health (T32MH014275, MH14275-15)
  • National Eye Institute (EY-07980)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Face Recognition and Perception
Keywords
primary visual cortex, macaque visual cortex, spatial frequency tuning, orientation selectivity, receptive field mapping, 2-deoxyglucose, cortical layers, V2, visual form processing
MeSH terms
Animals, Brain Mapping, Deoxyglucose, Macaca fascicularis, Models, Neurological, Neurons, Photic Stimulation, Space Perception, Visual Cortex, Vision, Monocular

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