Modeling the cell division cycle: cdc2 and cyclin interactions.
Open accessAbstract
The proteins cdc2 and cyclin form a heterodimer (maturation promoting factor) that controls the major events of the cell cycle. A mathematical model for the interactions of cdc2 and cyclin is constructed. Simulation and analysis of the model show that the control system can operate in three modes: as a steady state with high maturation promoting factor activity, as a spontaneous oscillator, or as an excitable switch. We associate the steady state with metaphase arrest in unfertilized eggs, the spontaneous oscillations with rapid division cycles in early embryos, and the excitable switch with growth-controlled division cycles typical of nonembryonic cells.
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By examining 17 models from the systems biology literature, the paper showed that their parameter sensitivities all share striking common features deemed "sloppiness".
“By examining 17 models from the systems biology literature [2,21,25,28–41], we showed that their parameter sensitivities all share striking common features deemed “sloppiness””
From Universally Sloppy Parameter Sensitivities in Systems Biology Models (2007) · cites this paper as [28]
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- Authors
- Tyson, J. J.
- Affiliations
- Virginia Tech (US)
- Corresponding author
- Tyson, J J
- ORCID
- Tyson, J J
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1991-08-15
- Volume
- 88
- Issue
- 16
- Pages
- 7328-7332
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC52288
- OpenAlex
- W1996195324
- Cited by
- 449
- References
- 0
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 8 · 2023: 16 · 2022: 15 · 2021: 19 · 2020: 16 · 2019: 14 · 2018: 11 · 2017: 16 · 2016: 15 · 2015: 29 · 2014: 21 · 2013: 15 · 2012: 25
- FWCI
- 1.85
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01gm036809-03)
- National Institute of General Medical Sciences (GM-36809)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene Regulatory Network Analysis
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Physical Sciences › Mathematics › Modeling and Simulation › Mathematical Biology Tumor Growth
- Keywords
- cell cycle, cdc2, cyclins, maturation-promoting factor, heterodimer, mathematical model, spontaneous oscillations, metaphase arrest, cell division, zygote, early embryo
- MeSH terms
- Animals, Cell Division, Kinetics, Mathematics, Mitosis, Models, Biological, Maturation-Promoting Factor, CDC2 Protein Kinase, Cyclins
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