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Cell-specific expression of mRNAs encoding Na+,K(+)-ATPase alpha- and beta-subunit isoforms within the rat central nervous system.
Open accessAbstract
We have used in situ hybridization histochemistry to analyze the subcellular distribution of mRNAs encoding Na,K-ATPase alpha- and beta-subunit isoforms in the rat central nervous system. Substantial differences in the cell-specific pattern of expression were found for the genes encoding three isoforms of the alpha subunit. Transcripts of alpha 1-subunit gene were detected in virtually all cell types and structures examined. Expression of alpha 2-subunit mRNA was characteristic of glia, whereas alpha 3-subunit transcripts were predominant in neurons. Transcripts encoding the beta 1 subunit were detected in neurons, whereas beta 2-subunit mRNA expression was characteristic of glia. mRNA encoding both beta-subunit isoforms was present in choroidal epithelial cells. The distribution pattern of alpha- and beta-subunit mRNAs in structures throughout the central nervous system is consistent with the possibility of six structurally distinct Na+,K(+)-ATPase isoenzymes.
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Cited by
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Brown, P. D., Davies, S. L., Speake, T., & Millar, I. D. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.07.003 · Cited by 451
Spicer, S. S., & Schulte, B. A. (1996) · Hearing Research · doi:10.1016/0378-5955(96)00106-2 · Cited by 301
Chun, J. T., Wang, L., Pasinetti, G. M., Finch, C. E., & Zlokovic, B. V. (1999) · Experimental Neurology · doi:10.1006/exnr.1999.7052 · Cited by 67
Metadata
- Authors
- Watts, A. G., Sanchez-Watts, G., Emanuel, J. R., & Levenson, R.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1991-08-15
- Volume
- 88
- Issue
- 16
- Pages
- 7425-7429
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2089719366
- Cited by
- 191
- References
- 0
- FWCI
- 3.55
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Cell-specific expression of mRNAs encoding Na+,K(+)-ATPase alpha- and beta-subunit isoforms within the rat central nervous system. https://app.cochat.ai/papers/10.1073/pnas.88.16.7425
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- Watts, A. G., Sanchez-Watts, G., Emanuel, J. R., & Levenson, R. (1991). Cell-specific expression of mRNAs encoding Na+,K(+)-ATPase alpha- and beta-subunit isoforms within the rat central nervous system. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.88.16.7425
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