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The receptor kinase family: primary structure of rhodopsin kinase reveals similarities to the beta-adrenergic receptor kinase.
Open accessAbstract
Light-dependent deactivation of rhodopsin as well as homologous desensitization of beta-adrenergic receptors involves receptor phosphorylation that is mediated by the highly specific protein kinases rhodopsin kinase (RK) and beta-adrenergic receptor kinase (beta ARK), respectively. We report here the cloning of a complementary DNA for RK. The deduced amino acid sequence shows a high degree of homology to beta ARK. In a phylogenetic tree constructed by comparing the catalytic domains of several protein kinases, RK and beta ARK are located on a branch close to, but separate from the cyclic nucleotide-dependent protein kinase and protein kinase C subfamilies. From the common structural features we conclude that both RK and beta ARK are members of a newly delineated gene family of guanine nucleotide-binding protein (G protein)-coupled receptor kinases that may function in diverse pathways to regulate the function of such receptors.
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Cited by
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Freedman, N. J., Liggett, S. B., Drachman, D. E., Pei, G., Caron, M. G., & Lefkowitz, R. J. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.30.17953 · Cited by 321
Self-citationIsoprenylation in regulation of signal transduction by G-protein-coupled receptor kinases
Inglese, J., Koch, W. J., Caron, M. G., & Lefkowitz, R. J. (1992) · Nature · doi:10.1038/359147a0 · Cited by 309
Self-citationSeven transmembrane receptors: something old, something new
Lefkowitz, R. J. (2007) · Acta Physiologica · doi:10.1111/j.1365-201x.2007.01693.x · Cited by 305
Self-citationA Brief History of G‐Protein Coupled Receptors (Nobel Lecture)
Lefkowitz, R. J. (2013) · Angewandte Chemie International Edition · doi:10.1002/anie.201301924 · Cited by 294
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Metadata
- Authors
- Lorenz, W., Inglese, J., Palczewski, K., Onorato, J. J., Caron, M. G., & Lefkowitz, R. J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1991-10
- Volume
- 88
- Issue
- 19
- Pages
- 8715-8719
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2071132058
- Cited by
- 189
- References
- 0
- FWCI
- 7.48
- Type
- journal article
- Language
- en
- Open access
- green
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- Lorenz, W., Inglese, J., Palczewski, K., Onorato, J. J., Caron, M. G., & Lefkowitz, R. J. (1991). The receptor kinase family: primary structure of rhodopsin kinase reveals similarities to the beta-adrenergic receptor kinase. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.88.19.8715
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