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An iron-carboxylate bond links the heme units of malaria pigment.
Open accessAbstract
The intraerythrocytic malaria parasite uses hemoglobin as a major nutrient source. Digestion of hemoglobin releases heme, which the parasite converts into an insoluble microcrystalline material called hemozoin or malaria pigment. We have purified hemozoin from the human malaria organism Plasmodium falciparum and have used infrared spectroscopy, x-ray absorption spectroscopy, and chemical synthesis to determine its structure. The molecule consists of an unusual polymer of hemes linked between the central ferric ion of one heme and a carboxylate side-group oxygen of another. The hemes are sequestered via this linkage into an insoluble product, providing a unique way for the malaria parasite to avoid the toxicity associated with soluble heme.
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Cited by
Massive chronic intervillositis of the placenta associated with malaria infection
Ordi, J., Ismail, M. R., Ventura, P. J., Kahigwa, E., Hirt, R., Cardesa, A., Alonso, P. L., & Menendez, C. (1998) · The American Journal of Surgical Pathology · doi:10.1097/00000478-199808000-00011 · Cited by 265
The Peculiarities and Paradoxes of Plasmodium Heme Metabolism
Sigala, P. A., & Goldberg, D. E. (2014) · Annual Review of Microbiology · doi:10.1146/annurev-micro-091313-103537 · Cited by 129
Self-citationHaemozoin: from melatonin pigment to drug target, diagnostic tool, and immune modulator
Hänscheid, T., Egan, T. J., & Grobusch, M. P. (2007) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(07)70238-4 · Cited by 128
Recent advances in antimalarial drug development
Vangapandu, S., Jain, M., Kaur, K., Patil, P., Patel, S. R., & Jain, R. (2007) · Medicinal Research Reviews · doi:10.1002/med.20062 · Cited by 108
Innate inflammatory response to the malarial pigment hemozoin
Shio, M. T., Kassa, F. A., Bellemare, M.-J., & Olivier, M. (2010) · Microbes and Infection · doi:10.1016/j.micinf.2010.07.001 · Cited by 96
Metadata
- Authors
- Slater, A. F., Swiggard, W. J., Orton, B. R., Flitter, W. D., Goldberg, D. E., Cerami, A., & Henderson, G. B.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1991-01-15
- Volume
- 88
- Issue
- 2
- Pages
- 325-329
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2121356018
- Cited by
- 511
- References
- 0
- FWCI
- 11.31
- Type
- journal article
- Language
- en
- Open access
- green
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- Slater, A. F., Swiggard, W. J., Orton, B. R., Flitter, W. D., Goldberg, D. E., Cerami, A., & Henderson, G. B. (1991). An iron-carboxylate bond links the heme units of malaria pigment. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.88.2.325
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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