The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Molecular cloning and characterization of a Ca2+/calmodulin-insensitive adenylyl cyclase from rat brain.
Open accessAbstract
Biochemical, immunological, and molecular cloning studies have suggested the existence of multiple forms of adenylyl cyclase (EC 4.6.1.1). An adenylyl cyclase cDNA clone (type II) was isolated from a rat brain library and found to encode a protein of 1090 amino acids that was homologous to but distinct from the previously described Ca2+/calmodulin-stimulated adenylyl cyclase from bovine brain. Expression of the type II cDNA in an insect cell line resulted in an increased level of adenylyl cyclase activity that was insensitive to Ca2+/calmodulin. Addition of activated Gs alpha protein to type II-containing membranes increased enzyme activity. The mRNA encoding the type II protein was expressed at high levels in brain tissue and at low levels in olfactory epithelium and lung. The existence of multiple adenylyl cyclase enzymes may provide for complex and distinct modes of biochemical regulation of cAMP levels in the brain.
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Cites
Livingstone, M. S., Sziber, P. P., & Quinn, W. G. (1984) · Cell · doi:10.1016/0092-8674(84)90316-7 · Cited by 587
Cited by
Type-Specific Regulation of Adenylyl Cyclase by G Protein βγ Subunits
Tang, W.-J., & Gilman, A. G. (1991) · Science · doi:10.1126/science.1962211 · Cited by 1,091
Self-citationComplexity and Diversity of Mammalian Adenylyl Cyclases
Sunahara, R. K., Dessauer, C. W., & Gilman, A. G. (1996) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.36.040196.002333 · Cited by 874
Self-citationMammalian Membrane-bound Adenylyl Cyclases
Taussig, R., & Gilman, A. G. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.1.1 · Cited by 721
Self-citationHormonal stimulation of adenylyl cyclase through Gi-protein βγ subunits
Federman, A. D., Conklin, B. R., Schrader, K. A., Reed, R. R., & Bourne, H. R. (1992) · Nature · doi:10.1038/356159a0 · Cited by 624
Self-citationThe Drosophila learning and memory gene rutabaga encodes a - adenylyl cyclase
Levin, L. R., Han, P.-L., Hwang, P. M., Feinstein, P. G., Davis, R. L., & Reed, R. R. (1992) · Cell · doi:10.1016/0092-8674(92)90185-f · Cited by 517
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Metadata
- Authors
- Feinstein, P. G., Schrader, K. A., Bakalyar, H. A., Tang, W. J., Krupinski, J., Gilman, A. G., & Reed, R. R.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1991-11-15
- Volume
- 88
- Issue
- 22
- Pages
- 10173-10177
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2078817376
- Cited by
- 285
- References
- 1
- FWCI
- 10.53
- Type
- journal article
- Language
- en
- Open access
- green
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- Feinstein, P. G., Schrader, K. A., Bakalyar, H. A., Tang, W. J., Krupinski, J., Gilman, A. G., & Reed, R. R. (1991). Molecular cloning and characterization of a Ca2+/calmodulin-insensitive adenylyl cyclase from rat brain. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.88.22.10173
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