The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Drift, admixture, and selection in human evolution: a study with DNA polymorphisms.
Open accessAbstract
Accuracy of evolutionary analysis of populations within a species requires the testing of a large number of genetic polymorphisms belonging to many loci. We report here a reconstruction of human differentiation based on 100 DNA polymorphisms tested in five populations from four continents. The results agree with earlier conclusions based on other classes of genetic markers but reveal that Europeans do not fit a simple model of independently evolving populations with equal evolutionary rates. Evolutionary models involving early admixture are compatible with the data. Taking one such model into account, we examined through simulation whether random genetic drift alone might explain the variation among gene frequencies across populations and genes. A measure of variation among populations was calculated for each polymorphism, and its distribution for the 100 polymorphisms was compared with that expected for a drift-only hypothesis. At least two-thirds of the polymorphisms appear to be selectively neutral, but there are significant deviations at the two ends of the observed distribution of the measure of variation: a slight excess of polymorphisms with low variation and a greater excess with high variation. This indicates that a few DNA polymorphisms are affected by natural selection, rarely heterotic, and more often disruptive, while most are selectively neutral.
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Cites
The neighbor-joining method: a new method for reconstructing phylogenetic trees.
(1987) · Molecular Biology and Evolution · doi:10.1093/oxfordjournals.molbev.a040454 · Cited by 59,715
EVOLUTION IN MENDELIAN POPULATIONS
Wright, S. (1931) · Genetics · doi:10.1093/genetics/16.2.97 · Cited by 8,916
Construction of a genetic linkage map in man using restriction fragment length polymorphisms.
Botstein, D., White, R. L., Skolnick, M. H., & Davis, R. W. (1980) · Europe PMC (PubMed Central) · Cited by 8,327
[21] Specific synthesis of DNA in vitro via a polymerase-catalyzed chain reaction
Mullis, K. B., & Faloona, F. A. (1987) · Methods in Enzymology · doi:10.1016/0076-6879(87)55023-6 · Cited by 5,694
Mitochondrial DNA and human evolution
Cann, R. L., Stoneking, M., & Wilson, A. C. (1987) · Nature · doi:10.1038/325031a0 · Cited by 3,100
Phylogenetic analysis: models and estimation procedures
(2018) · Phylogenetic Inference, Selection Theory, and History of Science · doi:10.1017/9781316276259.010 · Cited by 2,260
Saiki, R. K., Bugawan, T. L., Horn, G. T., Mullis, K. B., & Erlich, H. A. (1986) · Nature · doi:10.1038/324163a0 · Cited by 1,827
ESTIMATION OF THE COANCESTRY COEFFICIENT: BASIS FOR A SHORT-TERM GENETIC DISTANCE
Reynolds, J., Weir, B. S., & Cockerham, C. C. (1983) · Genetics · doi:10.1093/genetics/105.3.767 · Cited by 1,786
Relationships between gene trees and species trees.
(1988) · Molecular Biology and Evolution · doi:10.1093/oxfordjournals.molbev.a040517 · Cited by 1,622
The Genetics of Human Populations
J., A., Cavali-Sforza, L. L., & Bodmer, W. F. (1972) · Population (French Edition) · doi:10.2307/1529365 · Cited by 1,207
Cited by
Evaluating loci for use in the genetic analysis of population structure.
(1996) · Proceedings of the Royal Society of London. Series B: Biological Sciences · doi:10.1098/rspb.1996.0237 · Cited by 1,535
Positive Natural Selection in the Human Lineage
Sabeti, P. C., Schaffner, S. F., Fry, B., Lohmueller, J., Varilly, P., Shamovsky, O., Palma, A., Mikkelsen, T. S., Altshuler, D., & Lander, E. S. (2006) · Science · doi:10.1126/science.1124309 · Cited by 1,157
Use of Unlinked Genetic Markers to Detect Population Stratification in Association Studies
Pritchard, J. K., & Rosenberg, N. A. (1999) · The American Journal of Human Genetics · doi:10.1086/302449 · Cited by 1,198
Interrogating a High-Density SNP Map for Signatures of Natural Selection
Akey, J. M., Zhang, G., Zhang, K., Jin, L., & Shriver, M. D. (2002) · Genome Research · doi:10.1101/gr.631202 · Cited by 964
Bigham, A., Bauchet, M., Pinto, D., Mao, X., Akey, J. M., Mei, R., Scherer, S. W., Julian, C. G., Wilson, M. J., López Herráez, D., et al. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1001116 · Cited by 597
Metadata
- Authors
- Bowcock, A. M., Kidd, J. R., Mountain, J. L., Hebert, J. M., Carotenuto, L., Kidd, K. K., & Cavalli-Sforza, L. L.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1991-02
- Volume
- 88
- Issue
- 3
- Pages
- 839-843
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1987752391
- Cited by
- 414
- References
- 28
- FWCI
- 11.17
- Type
- journal article
- Language
- en
- Open access
- green
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- Bowcock, A. M., Kidd, J. R., Mountain, J. L., Hebert, J. M., Carotenuto, L., Kidd, K. K., & Cavalli-Sforza, L. L. (1991). Drift, admixture, and selection in human evolution: a study with DNA polymorphisms. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.88.3.839
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