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Single K+ channels in membrane patches of arterial chemoreceptor cells are modulated by O2 tension.
Open accessAbstract
Type I cells of the carotid body are known to participate in the detection of O2 tension in arterial blood but the primary chemotransduction mechanisms are not well understood. Here we report the existence in excised membrane patches of type I cells of a single K+ channel type modulated by changes in PO2. Open probability of the O2-sensitive K+ channel reversibly decreased by at least 50% on exposure to hypoxia but single-channel conductance (approximately 20 pS) was unaltered. In the range between 70 and 150 mmHg (1 mmHg = 133 Pa) the decrease of single-channel open probability was proportional to the PO2 measured in the vicinity of the membrane patch. The inhibition of K+ channel activity by low PO2 was independent of the presence of non-hydrolyzable guanine triphosphate analogues at the internal face of the membrane. The results indicate that the O2 sensor of type I cells is in the plasma membrane and suggest that environmental O2 interacts directly with the K+ channels.
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Cited by
Mitochondria in health and disease: perspectives on a new mitochondrial biology
Duchen, M. R. (2004) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2004.03.001 · Cited by 721
Peripheral Chemoreceptors: Function and Plasticity of the Carotid Body
Kumar, P., & Prabhakar, N. R. (2012) · Comprehensive Physiology · doi:10.1002/cphy.c100069 · Cited by 530
Oxygen sensing in airway chemoreceptors
Youngson, C., Nurse, C., Yeger, H., & Cutz, E. (1993) · Nature · doi:10.1038/365153a0 · Cited by 458
Regulation of fast inactivation of cloned mammalian IK(A) channels by cysteine oxidation
Ruppersberg, J. P., Stacker, M., Pongs, O., Heinemann, S. H., Frank, R., & Koenen, M. (1991) · Nature · doi:10.1038/352711a0 · Cited by 447
Cellular oxygen sensing by mitochondria: old questions, new insight
Chandel, N. S., & Schumacker, P. T. (2000) · Journal of Applied Physiology · doi:10.1152/jappl.2000.88.5.1880 · Cited by 391
Metadata
- Authors
- Ganfornina, M. D., & López-Barneo, J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1991-04
- Volume
- 88
- Issue
- 7
- Pages
- 2927-2930
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1975045654
- Cited by
- 158
- References
- 0
- FWCI
- 6.86
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Single K+ channels in membrane patches of arterial chemoreceptor cells are modulated by O2 tension. https://app.cochat.ai/papers/10.1073/pnas.88.7.2927
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- Ganfornina, M. D., & López-Barneo, J. (1991). Single K+ channels in membrane patches of arterial chemoreceptor cells are modulated by O2 tension. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.88.7.2927
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