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Cited by 390

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Inhibition of calcium oxalate crystal growth in vitro by uropontin: another member of the aspartic acid-rich protein superfamily.

Open access
Shiraga, H, Min, W, VanDusen, W J, Clayman, M D, Miner, D, Terrell, C H, Sherbotie, J R, Foreman, J W, Przysiecki, C, Neilson, E G·1992·Proceedings of the National Academy of Sciences

Abstract

The majority of human urinary stones are primarily composed of calcium salts. Although normal urine is frequently supersaturated with respect to calcium oxalate, most humans do not form stones. Inhibitors are among the multiple factors that may influence the complex process of urinary stone formation. We have isolated an inhibitor of calcium oxalate crystal growth from human urine by monoclonal antibody immunoaffinity chromatography. The N-terminal amino acid sequence and acidic amino acid content of this aspartic acid-rich protein, uropontin, are similar to those of other pontin proteins from bone, plasma, breast milk, and cells. The inhibitory effect of uropontin on calcium oxalate crystal growth in vitro supports the concept that pontins may have a regulatory role. This function would be analogous to that of other members of the aspartic acid-rich protein superfamily, which stereospecifically regulate the mineralization fronts of calcium-containing crystals.

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Crossref · 10.1073/pnas.89.1.426

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Metadata

Authors
Shiraga, H., Min, W., VanDusen, W. J., Clayman, M. D., Miner, D., Terrell, C. H., Sherbotie, J. R., Foreman, J. W., Przysiecki, C., & Neilson, E. G.
Venue
Proceedings of the National Academy of Sciences
Published
1992-01
Volume
89
Issue
1
Pages
426-430
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
OpenAlex
W2077279071
Cited by
390
References
1
FWCI
28.21
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Inhibition of calcium oxalate crystal growth in vitro by uropontin: another member of the aspartic acid-rich protein superfamily. https://app.cochat.ai/papers/10.1073/pnas.89.1.426
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Shiraga, H., Min, W., VanDusen, W. J., Clayman, M. D., Miner, D., Terrell, C. H., Sherbotie, J. R., Foreman, J. W., Przysiecki, C., & Neilson, E. G. (1992). Inhibition of calcium oxalate crystal growth in vitro by uropontin: another member of the aspartic acid-rich protein superfamily. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.89.1.426

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.