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Inhibition of calcium oxalate crystal growth in vitro by uropontin: another member of the aspartic acid-rich protein superfamily.
Open accessAbstract
The majority of human urinary stones are primarily composed of calcium salts. Although normal urine is frequently supersaturated with respect to calcium oxalate, most humans do not form stones. Inhibitors are among the multiple factors that may influence the complex process of urinary stone formation. We have isolated an inhibitor of calcium oxalate crystal growth from human urine by monoclonal antibody immunoaffinity chromatography. The N-terminal amino acid sequence and acidic amino acid content of this aspartic acid-rich protein, uropontin, are similar to those of other pontin proteins from bone, plasma, breast milk, and cells. The inhibitory effect of uropontin on calcium oxalate crystal growth in vitro supports the concept that pontins may have a regulatory role. This function would be analogous to that of other members of the aspartic acid-rich protein superfamily, which stereospecifically regulate the mineralization fronts of calcium-containing crystals.
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Cites
Soluble Protein of the Organic Matrix of Mollusk Shells: A Potential Template for Shell Formation
Weiner, S., & Hood, L. (1975) · Science · doi:10.1126/science.1188379 · Cited by 377
Cited by
Rittling, S. R., Matsumoto, H. N., Mckee, M. D., Nanci, A., An, X.-R., Novick, K. E., Kowalski, A. J., Noda, M., & Denhardt, D. T. (1998) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.1998.13.7.1101 · Cited by 438
Pathogenesis of cyclosporine nephropathy: roles of angiotensin II and osteopontin.
Pichler, R. H., Franceschini, N., Young, B. A., Hugo, C., Andoh, T. F., Burdmann, E. A., Shankland, S. J., Alpers, C. E., Bennett, W. M., & Couser, W. G. (1995) · Journal of the American Society of Nephrology · doi:10.1681/asn.v641186 · Cited by 256
A Biochemical Characterization of the Binding of Osteopontin to Integrins αvβ1 and αvβ5
Hu, D. D., Lin, E. C. K., Kovach, N. L., Hoyer, J. R., & Smith, J. W. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.44.26232 · Cited by 254
The influence of surface active molecules on the crystallization of biominerals in solution
Sikirić, M. D., & Füredi-Milhofer, H. (2006) · Advances in Colloid and Interface Science · doi:10.1016/j.cis.2006.11.022 · Cited by 100
Metadata
- Authors
- Shiraga, H., Min, W., VanDusen, W. J., Clayman, M. D., Miner, D., Terrell, C. H., Sherbotie, J. R., Foreman, J. W., Przysiecki, C., & Neilson, E. G.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1992-01
- Volume
- 89
- Issue
- 1
- Pages
- 426-430
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2077279071
- Cited by
- 390
- References
- 1
- FWCI
- 28.21
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Inhibition of calcium oxalate crystal growth in vitro by uropontin: another member of the aspartic acid-rich protein superfamily. https://app.cochat.ai/papers/10.1073/pnas.89.1.426
- The paper
- Shiraga, H., Min, W., VanDusen, W. J., Clayman, M. D., Miner, D., Terrell, C. H., Sherbotie, J. R., Foreman, J. W., Przysiecki, C., & Neilson, E. G. (1992). Inhibition of calcium oxalate crystal growth in vitro by uropontin: another member of the aspartic acid-rich protein superfamily. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.89.1.426
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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