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MT-III, a brain-specific member of the metallothionein gene family.
Open accessAbstract
A third member of the metallothionein (MT) gene family, designated MT-III, was cloned by virtue of its homology to a human protein that was shown previously to inhibit neuronal survival in culture and to be deficient in the brains of people with Alzheimer disease. Human and mouse MT-IIIs have two insertions relative to all other known mammalian MTs: a threonine after the fourth amino acid and a block of six amino acids near the carboxyl terminus. The genes encoding MT-III resemble all other mammalian MT genes in their small size and exon/intron organization. The MT-III genes are closely linked to the other functional MT genes on human chromosome 16 and mouse chromosome 8. Mouse MT-III gene expression appears to be restricted to brain; in addition, it fails to respond to zinc, cadmium, dexamethasone, or bacterial endotoxin in vivo, thereby distinguishing MT-III from other known MTs.
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Citations
Cited by
The Essential Toxin: Impact of Zinc on Human Health
Plum, L. M., Rink, L., & Haase, H. (2010) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph7041342 · Cited by 1,577
Metallothionein in the central nervous system: Roles in protection, regeneration and cognition
West, A. K., Hidalgo, J., Eddins, D., Levin, E. D., & Aschner, M. (2008) · NeuroToxicology · doi:10.1016/j.neuro.2007.12.006 · Cited by 190
Metadata
- Authors
- Palmiter, R. D., Findley, S. D., Whitmore, T. E., & Durnam, D. M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1992-07-15
- Volume
- 89
- Issue
- 14
- Pages
- 6333-6337
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2027452172
- Cited by
- 559
- References
- 0
- FWCI
- 19.39
- Type
- journal article
- Language
- en
- Open access
- green
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- Palmiter, R. D., Findley, S. D., Whitmore, T. E., & Durnam, D. M. (1992). MT-III, a brain-specific member of the metallothionein gene family. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.89.14.6333
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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