The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
A retinoic acid receptor alpha antagonist selectively counteracts retinoic acid effects.
Open accessAbstract
Retinoic acid (RA) exerts its pleiotropic effects on cell growth and differentiation through the activation of a family of transcription factors-the RA receptors (RARs). Three subtypes of these receptors exist, RAR alpha, RAR beta, and RAR gamma. The receptors are differentially expressed in different cell types and stages of development, suggesting that they may regulate different sets of genes. We have identified a synthetic retinoid with the characteristics of a selective RAR alpha antagonist. This antagonist counteracts RA effects on HL-60 cell differentiation and on B-lymphocyte polyclonal activation. Beyond its potential practical relevance, this and other specific antagonists will be useful to dissect the RAR system and to assign to one given receptor each of the many RA-regulated functions.
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Cites
A human retinoic acid receptor which belongs to the family of nuclear receptors
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Induction of differentiation of the human promyelocytic leukemia cell line (HL-60) by retinoic acid
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Identification of a receptor for the morphogen retinoic acid
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9-cis retinoic acid is a high affinity ligand for the retinoid X receptor
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Cited by
Lengqvist, J., Mata de Urquiza, A., Bergman, A.-C., Willson, T. M., Sjövall, J., Perlmann, T., & Griffiths, W. J. (2004) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m400003-mcp200 · Cited by 323
Jinushi, M., Takehara, T., Tatsumi, T., Kanto, T., Groh, V., Spies, T., Kimura, R., Miyagi, T., Mochizuki, K., Sasaki, Y., et al. (2003) · International Journal of Cancer · doi:10.1002/ijc.10966 · Cited by 244
Retinoic Acid Signaling Is Essential for Embryonic Hematopoietic Stem Cell Development
Chanda, B., Ditadi, A., Iscove, N. N., & Keller, G. (2013) · Cell · doi:10.1016/j.cell.2013.08.055 · Cited by 201
ATRA and KL promote differentiation toward the meiotic program of male germ cells.
Pellegrini, M., Filipponi, D., Gori, M., Barrios, F., Lolicato, F., Grimaldi, P., Rossi, P., Jannini, E. A., Geremia, R., & Dolci, S. (2008) · Cell Cycle · doi:10.4161/cc.7.24.7262 · Cited by 126
Radaeva, S., Wang, L., Radaev, S., Jeong, W.-I., Park, O., & Gao, B. (2007) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00212.2007 · Cited by 123
Metadata
- Authors
- Apfel, C., Bauer, F., Crettaz, M., Forni, L., Kamber, M., Kaufmann, F., LeMotte, P., Pirson, W., & Klaus, M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1992-08
- Volume
- 89
- Issue
- 15
- Pages
- 7129-7133
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2016525543
- Cited by
- 250
- References
- 5
- FWCI
- 4.20
- Type
- journal article
- Language
- en
- Open access
- green
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- Apfel, C., Bauer, F., Crettaz, M., Forni, L., Kamber, M., Kaufmann, F., LeMotte, P., Pirson, W., & Klaus, M. (1992). A retinoic acid receptor alpha antagonist selectively counteracts retinoic acid effects. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.89.15.7129
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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