The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Reconstruction of genomic rearrangements in great apes and gibbons by chromosome painting.
Open accessAbstract
The homology between hylobatid chromosomes and other primates has long remained elusive. We used chromosomal in situ suppression hybridization of all human chromosome-specific DNA libraries to "paint" the chromosomes of primates and establish homologies between the human, great ape (chimpanzee, gorilla, and orangutan), and gibbon karyotypes (Hylobates lar species group, 2n = 44). The hybridization patterns unequivocally demonstrate the high degree of chromosomal homology and synteny of great ape and human chromosomes. Relative to human, no translocations were detected in great apes, except for the well-known fusion-origin of human chromosome 2 and a 5;17 translocation in the gorilla. In contrast, numerous translocations were detected that have led to the massive reorganization of the gibbon karyotype: the 22 autosomal human chromosomes have been divided into 51 elements to compose the 21 gibbon autosomes. Molecular cytogenetics promises to finally allow hylobatids to be integrated into the overall picture of chromosomal evolution in the primates.
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“Hylobatidae (siamang, gibbons, hoolock) are noted for exceptional rates of chromosome re-arrangement [52], [53], 10–20 times faster than in most mammals [54].”
From A molecular phylogeny of living primates (2011) · cites this paper as [53]
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Cites
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A molecular phylogeny of living primates
Perelman, P., Johnson, W. E., Roos, C., Seuánez, H. N., Horvath, J. E., Moreira, M. A. M., Kessing, B., Pontius, J., Roelke, M., Rumpler, Y., et al. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1001342 · Cited by 1,414
Genomic Plasticity and the Diversity of Polyploid Plants
Leitch, A. R., & Leitch, I. J. (2008) · Science · doi:10.1126/science.1153585 · Cited by 881
Shaikh, T. H. (2000) · Human Molecular Genetics · doi:10.1093/hmg/9.4.489 · Cited by 531
The Promise of Comparative Genomics in Mammals
O’Brien, S. J., Menotti-Raymond, M. A., Murphy, W. J., Nash, W. G., Wienberg, J., Stanyon, R., Copeland, N. G., Jenkins, N. A., Womack, J. E., & Graves, J. A. M. (1999) · Science · doi:10.1126/science.286.5439.458 · Cited by 450
Self-citationEvolutionary conservation of chromosome territory arrangements in cell nuclei from higher primates
Tanabe, H., Müller, S., Neusser, M., Hase, J. V., Calcagno, E., Cremer, M., Solovei, I. V., Cremer, C. G., & Cremer, T. J. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.072618599 · Cited by 412
Self-citation
Metadata
- Authors
- Jauch, A., Wienberg, J., Stanyon, R., Arnold, N., Tofanelli, S., Ishida, T., & Cremer, T.
- Affiliations
- Heidelberg University (DE)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1992-09-15
- Volume
- 89
- Issue
- 18
- Pages
- 8611-8615
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC49970
- OpenAlex
- W1999757424
- Cited by
- 310
- References
- 17
- Citations by year
- 2026: 4 · 2025: 1 · 2024: 5 · 2023: 3 · 2022: 1 · 2021: 4 · 2020: 4 · 2019: 6 · 2018: 5 · 2017: 4 · 2016: 6 · 2015: 8 · 2014: 8 · 2013: 4 · 2012: 9
- FWCI
- 11.84
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- CINECA IRIS Institutial research information system (University of Pisa) (submittedVersion)
- Open access LMU (Ludwid Maxmilian's Universitat Munchen) (submittedVersion)
- Florence Research (University of Florence) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Chromosomal and Genetic Variations
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genomic variations and chromosomal abnormalities
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genome Rearrangement Algorithms
- Keywords
- chromosome painting, chromosome homology, synteny, karyotype evolution, translocation, great apes, gibbons, Hylobates, 17 translocation, gorillas, orangutans, chimpanzees, molecular cytogenetics
- MeSH terms
- Animals, Chromosome Mapping, Chromosomes, Biological Evolution, Hylobates, Karyotyping, Nucleic Acid Hybridization, Species Specificity, Hominidae
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