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Comparison of the NMR solution structure and the x-ray crystal structure of rat metallothionein-2.
Open accessAbstract
Metallothioneins are small cysteine-rich proteins capable of binding heavy metal ions such as Zn2+ and Cd2+. They are ubiquitous tissue components in higher organisms, which tentatively have been attributed both unspecific protective functions against toxic metal ions and highly specific roles in fundamental zinc-regulated cellular processes. In this paper a detailed comparison of the NMR solution structure [Schultze, P., Wörgötter, E., Braun, W., Wagner, G., Vasák, M., Kägi, J. H. R. & Wüthrich, K. (1988) J. Mol. Biol. 203, 251-268] and a recent x-ray crystal structure [Robbins, A. H., McRee, D. E., Williamson, M., Collett, S. A., Xoung, N. H., Furey, W. F., Wang, B. C. & Stout, C. D. (1991) J. Mol. Biol. 221, 1269-1293] of rat metallothionein-2 shows that the metallothionein structures in crystals and in solution have identical molecular architectures. The structures obtained with both techniques now present a reliable basis for discussions on structure-function correlations in this class of metalloproteins.
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Citations
Cited by
Structural and Functional Aspects of Metal Sites in Biology
Holm, R. H., Kennepohl, P., & Solomon, E. I. (1996) · Chemical Reviews · doi:10.1021/cr9500390 · Cited by 2,541
Chen, B., Yu, P., Chan, W. N., Xie, F., Zhang, Y., Liang, L., Leung, K. T., Lo, K. W., Yu, J., Tse, G. M. K., et al. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01679-y · Cited by 420
Advances in the structure and chemistry of metallothioneins
Romero-Isart, N., & Vašák, M. (2002) · Journal of Inorganic Biochemistry · doi:10.1016/s0162-0134(01)00347-6 · Cited by 279
Kinetics of Zinc and Cadmium Exchanges between Metallothionein and Carbonic Anhydrase
Pinter, T. B. J., & Stillman, M. J. (2015) · Biochemistry · doi:10.1021/acs.biochem.5b00912 · Cited by 27
Metadata
- Authors
- Braun, W., Vasák, M., Robbins, A. H., Stout, C. D., Wagner, G., Kägi, J. H., & Wüthrich, K.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1992-11
- Volume
- 89
- Issue
- 21
- Pages
- 10124-10128
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1980139350
- Cited by
- 231
- References
- 0
- FWCI
- 4.31
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Braun, W., Vasák, M., Robbins, A. H., Stout, C. D., Wagner, G., Kägi, J. H., & Wüthrich, K. (1992). Comparison of the NMR solution structure and the x-ray crystal structure of rat metallothionein-2. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.89.21.10124
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