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Cell division arrest induced by phorbol ester in CHO cells overexpressing protein kinase C-delta subspecies.
Open accessAbstract
Several lines of CHO cells stably overexpressing protein kinase C (PKC) subspecies to various extents were established by the DNA-mediated transfer. Upon treatment with phorbol 12-myristate 13-acetate, the growth of the cells expressing the PKC-delta subspecies was markedly inhibited, whereas cell lines expressing PKC-alpha, PKC-beta II, and PKC-zeta subspecies were not significantly affected. Flow cytometric analysis indicated that all cell lines overexpressing PKC-delta subspecies accumulated in G2/M phase in response to phorbol 12-myristate 13-acetate. In these arrested cells, dikaryons were predominant, implying that phorbol ester-induced inhibition of cell division is specific to telophase. These results suggest PKC-delta subspecies may play a role in the normal cell cycle progression.
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Citations
Cited by
Structural Basis of Protein Kinase C Isoform Function
Steinberg, S. F. (2008) · Physiological Reviews · doi:10.1152/physrev.00034.2007 · Cited by 872
Takahashi, A., Ohtani, N., Yamakoshi, K., Iida, S.-I., Tahara, H., Nakayama, K., Nakayama, K. I., Ide, T., Saya, H., & Hara, E. (2006) · Nature Cell Biology · doi:10.1038/ncb1491 · Cited by 528
Díaz-Meco, M. T., Municio, M. M., Frutos, S., Sanchez, P., Lozano, J., Sanz, L., & Moscat, J. (1996) · Cell · doi:10.1016/s0092-8674(00)80152-x · Cited by 361
Ramsey, M. R., & Sharpless, N. E. (2006) · Nature Cell Biology · doi:10.1038/ncb1106-1213 · Cited by 237
Wang, Q. J., Acs, P., Goodnight, J., Giese, T., Blumberg, P. M., Mischak, H., & Mushinski, J. F. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.1.76 · Cited by 47
Metadata
- Authors
- Watanabe, T., Ono, Y., Taniyama, Y., Hazama, K., Igarashi, K., Ogita, K., Kikkawa, U., & Nishizuka, Y.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1992-11
- Volume
- 89
- Issue
- 21
- Pages
- 10159-10163
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2080275316
- Cited by
- 296
- References
- 0
- FWCI
- 5.09
- Type
- journal article
- Language
- en
- Open access
- green
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- Watanabe, T., Ono, Y., Taniyama, Y., Hazama, K., Igarashi, K., Ogita, K., Kikkawa, U., & Nishizuka, Y. (1992). Cell division arrest induced by phorbol ester in CHO cells overexpressing protein kinase C-delta subspecies. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.89.21.10159
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