The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.
Identification of a human src homology 2-containing protein-tyrosine-phosphatase: a putative homolog of Drosophila corkscrew.
Open accessAbstract
src homology 2 (SH2) domains direct binding to specific phosphotyrosyl proteins. Recently, SH2-containing protein-tyrosine-phosphatases (PTPs) were identified. Using degenerate oligonucleotides and the PCR, we have cloned a cDNA for an additional PTP, SH-PTP2, which contains two SH2 domains and is expressed ubiquitously. When expressed in Escherichia coli, SH-PTP2 displays tyrosine-specific phosphatase activity. Strong sequence similarity between SH-PTP2 and the Drosophila gene corkscrew (csw) and their similar patterns of expression suggest that SH-PTP2 is the human corkscrew homolog. Sequence comparisons between SH-PTP2, SH-PTP1, corkscrew, and other SH2-containing proteins suggest the existence of a subfamily of SH2 domains found specifically in PTPs, whereas comparison of the PTP domains of the SH2-containing PTPs with other tyrosine phosphatases suggests the existence of a subfamily of PTPs containing SH2 domains. Since corkscrew, a member of the terminal class signal transduction pathway, acts in concert with D-raf to positively transduce the signal generated by the receptor tyrosine kinase torso, these findings suggest several mechanisms by which SH-PTP2 may participate in mammalian signal transduction.
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Metadata
- Authors
- Freeman, R. M., Plutzky, J., & Neel, B. G.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1992-12
- Volume
- 89
- Issue
- 23
- Pages
- 11239-11243
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1968472053
- Cited by
- 360
- References
- 54
- FWCI
- 11.96
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Identification of a human src homology 2-containing protein-tyrosine-phosphatase: a putative homolog of Drosophila corkscrew. https://app.cochat.ai/papers/10.1073/pnas.89.23.11239
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- Freeman, R. M., Plutzky, J., & Neel, B. G. (1992). Identification of a human src homology 2-containing protein-tyrosine-phosphatase: a putative homolog of Drosophila corkscrew. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.89.23.11239
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