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Pax-2 is a DNA-binding protein expressed in embryonic kidney and Wilms tumor.
Open accessAbstract
The murine Pax-2 gene contains a protein coding domain homologous to the Drosophila paired-box, first described in certain developmental control genes of the segmentation type. Polyclonal antibodies recognize two Pax-2 proteins that are encoded by differentially spliced mRNAs. The Pax-2 proteins can bind a DNA sequence known to interact with the paired domain of a Drosophila protein. By immunocytochemistry, expression of Pax-2 could be localized to the nuclei of condensing mesenchyme cells and their epithelial derivatives in the developing kidney. Expression is abruptly down-regulated as the tubular epithelium differentiates. High levels of Pax-2 expression could also be detected in the epithelial cells of human Wilms tumors. These data suggest that Pax-2 is a transcription factor active during the mesenchyme-to-epithelium transition in early kidney development and in Wilms tumor.
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Metadata
- Authors
- Dressler, G. R., & Douglass, E. C.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1992-02-15
- Volume
- 89
- Issue
- 4
- Pages
- 1179-1183
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1993974403
- Cited by
- 407
- References
- 0
- FWCI
- 7.76
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Dressler, G. R., & Douglass, E. C. (1992). Pax-2 is a DNA-binding protein expressed in embryonic kidney and Wilms tumor. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.89.4.1179
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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