The DOI matches its Crossref record.
Stable growth transformation of human T lymphocytes by herpesvirus saimiri.
Open accessAbstract
Herpesvirus saimiri induces T-cell lymphomas in various species of New World monkeys and in rabbits, and it is able to immortalize monkey T lymphocytes in vitro. Sequences responsible for these effects have been localized to a region of the genome that varies significantly among the virus subgroups A, B, and C. We now report that infection of human blood lymphocytes and thymocytes with strains of subgroup C, in contrast to viruses of the other subgroups, yields continuously proliferating T-cell lines with the phenotype of mature CD4- or CD8-positive cells. Infection with strains of Herpes-virus saimiri subgroup C can thus be used to generate human T-cell lines for a variety of immunological and developmental studies.
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Cited by
Afzali, B., Lombardi, G., Lechler, R. I., & Lord, G. M. (2007) · Clinical and Experimental Immunology · doi:10.1111/j.1365-2249.2007.03356.x · Cited by 762
Impairment of immunity to Candida and Mycobacterium in humans with bi-allelic RORC mutations
Okada, S., Markle, J. G., Deenick, E. K., Mele, F., Averbuch, D., Lagos, M., Alzahrani, M., Al-Muhsen, S., Halwani, R., Ma, C. S., et al. (2015) · Science · doi:10.1126/science.aaa4282 · Cited by 413
Metadata
- Authors
- Biesinger, B., Müller-Fleckenstein, I., Simmer, B., Lang, G., Wittmann, S., Platzer, E., Desrosiers, R. C., & Fleckenstein, B.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1992-04
- Volume
- 89
- Issue
- 7
- Pages
- 3116-3119
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1972636814
- Cited by
- 290
- References
- 0
- FWCI
- 5.93
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Stable growth transformation of human T lymphocytes by herpesvirus saimiri. https://app.cochat.ai/papers/10.1073/pnas.89.7.3116
- The paper
- Biesinger, B., Müller-Fleckenstein, I., Simmer, B., Lang, G., Wittmann, S., Platzer, E., Desrosiers, R. C., & Fleckenstein, B. (1992). Stable growth transformation of human T lymphocytes by herpesvirus saimiri. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.89.7.3116
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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