The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
The gamma 1(34.5) gene of herpes simplex virus 1 precludes neuroblastoma cells from triggering total shutoff of protein synthesis characteristic of programed cell death in neuronal cells.
Open accessAbstract
The gamma 1(34.5) gene of herpes simplex virus 1 was previously shown to play a role in viral virulence since deletion of the gene reduced by a factor of approximately 100,000 the capacity of the virus to replicate in the central nervous system and cause mortality in the mouse. Here we show that in the human neuroblastoma cell line SK-N-SH of neuronal origin gamma 1(34.5) null mutants expressed early proteins, viral DNA, and mRNA of late genes. However, the onset of viral DNA synthesis triggered complete cessation of incorporation of radioactive precursors into proteins. The mutant and wild-type viruses replicated and could not be differentiated in cell lines or cell strains of nonneuronal origin. The results indicate that in the absence of the gamma 1(34.5) gene the SK-N-SH neuroblastoma cells triggered a response similar to the programed cell death of neuronal cells induced by metabolic stress. The gamma 1(34.5) protein precludes this cell response possibly in order to enable the protein synthesis necessary for viral replication.
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The Complete DNA Sequence of the Long Unique Region in the Genome of Herpes Simplex Virus Type 1
McGeoch, D. J., Dalrymple, M. A., Davison, A. J., Dolan, A., Frame, M. C., McNab, D., Perry, L. J., Scott, J. E., & Taylor, P. (1988) · Journal of General Virology · doi:10.1099/0022-1317-69-7-1531 · Cited by 1,618
Henderson, S., Rowe, M., Gregory, C., Croom-Carter, D., Wang, F., Longnecker, R., Kieff, E., & Rickinson, A. (1991) · Cell · doi:10.1016/0092-8674(91)90007-l · Cited by 1,168
Ejercito, P. M., Kieff, E. D., & Roizman, B. (1968) · Journal of General Virology · doi:10.1099/0022-1317-2-3-357 · Cited by 875
Self-citationProgrammed cell death: Apoptosis and oncogenesis
Williams, G. T. (1991) · Cell · doi:10.1016/0092-8674(91)90002-g · Cited by 826
Chou, J., Kern, E. R., Whitley, R. J., & Roizman, B. (1990) · Science · doi:10.1126/science.2173860 · Cited by 711
Self-citationIL-2 addiction: withdrawal of growth factor activates a suicide program in dependent T cells.
Duke, R. C., & Cohen, J. (1986) · PubMed · Cited by 382
Inverted Repetitions in the Chromosome of Herpes Simplex Virus
Sheldrick, P., & Berthelot, N. (1974) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.1974.039.01.080 · Cited by 356
Herpes simplex virus virion host shutoff function
Kwong, A. D., Kruper, J. A., & Frenkel, N. (1988) · Journal of Virology · doi:10.1128/jvi.62.3.912-921.1988 · Cited by 344
Morse, L. S., Pereira, L., Roizman, B., & Schaffer, P. A. (1978) · Journal of Virology · doi:10.1128/jvi.26.2.389-410.1978 · Cited by 337
Self-citationHoness, R. W., & Roizman, B. (1973) · Journal of Virology · doi:10.1128/jvi.12.6.1347-1365.1973 · Cited by 297
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Andtbacka, R. H. I., Kaufman, H. L., Collichio, F., Amatruda, T., Senzer, N., Chesney, J., Delman, K. A., Spitler, L. E., Puzanov, I., Agarwala, S. S., et al. (2015) · Journal of Clinical Oncology · doi:10.1200/jco.2014.58.3377 · Cited by 2,634
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Orvedahl, A., Alexander, D., Tallóczy, Z., Sun, Q., Wei, Y., Zhang, W., Burns, D., Leib, D. A., & Levine, B. (2007) · Cell Host & Microbe · doi:10.1016/j.chom.2006.12.001 · Cited by 857
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Metadata
- Authors
- Chou, J., & Roizman, B.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1992-04-15
- Volume
- 89
- Issue
- 8
- Pages
- 3266-3270
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1998342624
- Cited by
- 393
- References
- 25
- FWCI
- 14.10
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: The gamma 1(34.5) gene of herpes simplex virus 1 precludes neuroblastoma cells from triggering total shutoff of protein synthesis characteristic of programed cell death in neuronal cells. https://app.cochat.ai/papers/10.1073/pnas.89.8.3266
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- Chou, J., & Roizman, B. (1992). The gamma 1(34.5) gene of herpes simplex virus 1 precludes neuroblastoma cells from triggering total shutoff of protein synthesis characteristic of programed cell death in neuronal cells. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.89.8.3266
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