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What drives the translocation of proteins?
Open accessAbstract
We propose that protein translocation across membranes is driven by biased random thermal motion. This "Brownian ratchet" mechanism depends on chemical asymmetries between the cis and trans sides of the membrane. Several mechanisms could contribute to rectifying the thermal motion of the protein, such as binding and dissociation of chaperonins to the translocating chain, chain coiling induced by pH and/or ionic gradients, glycosylation, and disulfide bond formation. This helps explain the robustness and promiscuity of these transport systems.
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Randall, L. L. (1983) · Cell · doi:10.1016/0092-8674(83)90352-5 · Cited by 234
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Metadata
- Authors
- Simon, S. M., Peskin, C. S., & Oster, G. F.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1992-05
- Volume
- 89
- Issue
- 9
- Pages
- 3770-3774
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2094197811
- Cited by
- 422
- References
- 1
- FWCI
- 14.37
- Type
- journal article
- Language
- en
- Open access
- green
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- Simon, S. M., Peskin, C. S., & Oster, G. F. (1992). What drives the translocation of proteins? Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.89.9.3770
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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
