The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
The multidrug resistance (mdr1) gene product functions as an ATP channel.
Open accessAbstract
The multidrug resistance (mdr1) gene product, P-glycoprotein, is responsible for the ATP-dependent extrusion of a variety of compounds, including chemotherapeutic drugs, from cells. The data presented here show that cells with increased levels of the P-glycoprotein release ATP to the medium in proportion to the concentration of the protein in their plasma membrane. Furthermore, measurements of whole-cell and single-channel currents with patch-clamp electrodes indicate that the P-glycoprotein serves as an ATP-conducting channel in the plasma membrane. These findings suggest an unusual role for the P-glycoprotein.
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Cites
Hamill, O. P., Marty, A., Neher, E., Sakmann, B., & Sigworth, F. J. (1981) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00656997 · Cited by 18,436
Cited by
Intercellular Ca2+Waves: Mechanisms and Function
Leybaert, L., & Sanderson, M. J. (2012) · Physiological Reviews · doi:10.1152/physrev.00029.2011 · Cited by 331
Metadata
- Authors
- Abraham, E. H., Prat, A. G., Gerweck, L., Seneveratne, T., Arceci, R. J., Kramer, R., Guidotti, G., & Cantiello, H. F.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1993-01
- Volume
- 90
- Issue
- 1
- Pages
- 312-316
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2014235031
- Cited by
- 374
- References
- 1
- FWCI
- 14.42
- Type
- journal article
- Language
- en
- Open access
- green
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- Abraham, E. H., Prat, A. G., Gerweck, L., Seneveratne, T., Arceci, R. J., Kramer, R., Guidotti, G., & Cantiello, H. F. (1993). The multidrug resistance (mdr1) gene product functions as an ATP channel. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.90.1.312
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