The abnormal phosphorylation of tau protein at Ser-202 in Alzheimer disease recapitulates phosphorylation during development.
Open accessAbstract
Tau is a neuronal phosphoprotein whose expression is developmentally regulated. A single tau isoform is expressed in fetal human brain but six isoforms are expressed in adult brain, with the fetal isoform corresponding to the shortest of the adult isoforms. Phosphorylation of tau is also developmentally regulated, as fetal tau is phosphorylated at more sites than adult tau. In Alzheimer disease, the six adult tau isoforms become abnormally phosphorylated and form the paired helical filament, the major fibrous component of the characteristic neurofibrillary lesions. We show here that Ser-202 (in the numbering of the longest human brain tau isoform) is a phosphorylation site that distinguishes fetal from adult tau and we identify it as one of the abnormal phosphorylation sites in Alzheimer disease. The abnormal phosphorylation of tau at Ser-202 in Alzheimer disease thus recapitulates normal phosphorylation during development.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Many phosphorylated residues in PHF-tau are serines or threonines followed by proline.
“Prior studies have shown that many phosphorylated residues in PHF-tau are serines or threonines followed by a proline [1,6,8,11].”
From Glycogen synthase kinase-3β phosphorylates tau protein at multiple sites in intact cells (1995) · cites this paper as [6]
No citation lists for this paper
No citation lists for this paper yet — checked again daily.
References 36 · Cited by 446
- Authors
- Goedert, M., Jakes, R., Crowther, R. A., Six, J., Lübke, U., Vandermeeren, M., Cras, P., Trojanowski, J. Q., & Lee, V. M.
- Affiliations
- MRC Laboratory of Molecular Biology (GB)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1993-06
- Volume
- 90
- Issue
- 11
- Pages
- 5066-5070
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC46655
- OpenAlex
- W1965232330
- Cited by
- 446
- References
- 36
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 4 · 2023: 5 · 2022: 9 · 2021: 7 · 2020: 5 · 2019: 9 · 2018: 8 · 2017: 11 · 2016: 11 · 2015: 13 · 2014: 10 · 2013: 10 · 2012: 10
- FWCI
- 24.19
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01ag009399-05, 5r01ag010210-10)
- National Institute on Aging (P30AG010124, AG-10124, AG-10210, AG-09399)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- tau protein, Alzheimer's disease, tau isoforms, fetal brain, paired helical filaments, neurofibrillary tangles, phosphorylation sites
- MeSH terms
- Adult, Aging, Alzheimer Disease, Amino Acid Sequence, Animals, Brain, Cerebral Cortex, Fetus, Humans, Infant, Newborn, Phosphorylation, Protein Kinases, Recombinant Proteins, Serine, Restriction Mapping, Mutagenesis, Site-Directed, tau Proteins, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
