The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
EBNA-5, an Epstein-Barr virus-encoded nuclear antigen, binds to the retinoblastoma and p53 proteins.
Open accessAbstract
Epstein-Barr virus (EBV) immortalized human lymphoblastoid cell lines express six virally encoded nuclear proteins, designated EBV nuclear antigens 1-6 (EBNA-1-6). We show that the EBNA-5 protein (alternatively designated EBNA-LP) that is required for B-cell transformation can form a molecular complex with the retinoblastoma (RB) and p53 tumor suppressor proteins. Using EBNA-5 deletion mutants, we have found that a 66-amino acid-long peptide, encoded by the W repeat of the EBV genome, is sufficient for binding. Point mutations of RB and p53 that inhibit their complexing with other DNA viral oncoproteins do not affect their binding to EBNA-5. p53 competes with RB for EBNA-5 binding. Our data suggest that the mechanisms involved in EBV transformation may include impairment of RB and p53 function.
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Citations
Cites
The human papilloma virus-16 E7-oncoprotein is able to bind to the retinoblastoma gene product
Dyson, N., Howley, P. M., Münger, K., & Harlow, E. (1989) · Science · doi:10.1126/science.2537532 · Cited by 3,017
Whyte, P., Buchkovich, K. J., Horowitz, J. M., Friend, S. H., Raybuck, M., Weinberg, R. A., & Harlow, E. (1988) · Nature · doi:10.1038/334124a0 · Cited by 1,403
p53 is frequently mutated in Burkitt's lymphoma cell lines
Farrell, P. J., Allan, G. J., Shanahan, F., Vousden, K. H., & Crook, T. (1991) · The EMBO Journal · doi:10.1002/j.1460-2075.1991.tb07837.x · Cited by 254
Metadata
- Authors
- Szekely, L., Selivanova, G., Magnusson, K. P., Klein, G., & Wiman, K. G.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1993-06-15
- Volume
- 90
- Issue
- 12
- Pages
- 5455-5459
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2023530705
- Cited by
- 309
- References
- 3
- FWCI
- 10.26
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: EBNA-5, an Epstein-Barr virus-encoded nuclear antigen, binds to the retinoblastoma and p53 proteins. https://app.cochat.ai/papers/10.1073/pnas.90.12.5455
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- Szekely, L., Selivanova, G., Magnusson, K. P., Klein, G., & Wiman, K. G. (1993). EBNA-5, an Epstein-Barr virus-encoded nuclear antigen, binds to the retinoblastoma and p53 proteins. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.90.12.5455
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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