The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
A receptor tyrosine kinase found in breast carcinoma cells has an extracellular discoidin I-like domain.
Open accessAbstract
We have identified a breast carcinoma tyrosine phosphoprotein, discoidin domain receptor (DDR), that defines an unusual class of receptor tyrosine kinases. The DDR cDNA predicts a C-terminal tyrosine kinase domain and an N-terminal domain similar to the Dictyostelium discoideum lectin discoidin I. These domains are connected by an extraordinary hydrophilic proline/glycine-rich domain, which is interrupted by a predicted transmembrane sequence. This extended proline/glycine-rich region may be required for an unusual geometry of interaction with ligand or substrates. Discoidin I domains are also found in other proteins, including coagulation factors V and VIII, and may represent a class of domains that interact with specific cell surface molecules.
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Cites
Ellis, L., Clauser, E., Morgan, D. O., Edery, M., Roth, R. A., & Rutter, W. J. (1986) · Cell · doi:10.1016/0092-8674(86)90786-5 · Cited by 1,070
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Cited by
The Discoidin Domain Receptor Tyrosine Kinases Are Activated by Collagen
Vogel, W., Gish, G. D., Alves, F., & Pawson, T. (1997) · Molecular Cell · doi:10.1016/s1097-2765(00)80003-9 · Cited by 1,002
Structural and functional characterisation of cardiac fibroblasts
CAMELLITI, P., BORG, T., & KOHL, P. (2005) · Cardiovascular Research · doi:10.1016/j.cardiores.2004.08.020 · Cited by 930
Peles, E., Nativ, M., Lustig, M., Grumet, M., Schilling, J., Martinez, R., Plowman, G. D., & Schlessinger, J. (1997) · The EMBO Journal · doi:10.1093/emboj/16.5.978 · Cited by 400
Discoidin Domain Receptor Functions in Physiological and Pathological Conditions
(2014) · International Review of Cell and Molecular Biology · doi:10.1016/b978-0-12-800180-6.00002-5 · Cited by 395
Sensing extracellular matrix: An update on discoidin domain receptor function
Vogel, W. F., Abdulhussein, R., & Ford, C. E. (2006) · Cellular Signalling · doi:10.1016/j.cellsig.2006.02.012 · Cited by 368
Metadata
- Authors
- Johnson, J. D., Edman, J. C., & Rutter, W. J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1993-06-15
- Volume
- 90
- Issue
- 12
- Pages
- 5677-5681
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2082994012
- Cited by
- 182
- References
- 1
- FWCI
- 3.12
- Type
- journal article
- Language
- en
- Open access
- green
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- Johnson, J. D., Edman, J. C., & Rutter, W. J. (1993). A receptor tyrosine kinase found in breast carcinoma cells has an extracellular discoidin I-like domain. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.90.12.5677
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
