The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Escherichia coli cell division protein FtsZ is a guanine nucleotide binding protein.
Open accessAbstract
FtsZ is an essential cell division protein in Escherichia coli that forms a ring structure at the division site under cell cycle control. The dynamic nature of the FtsZ ring suggests possible similarities to eukaryotic filament forming proteins such as tubulin. In this study we have determined that FtsZ is a GTP/GDP binding protein with GTPase activity. A short segment of FtsZ is homologous to a segment in tubulin believed to be involved in the interaction between tubulin and guanine nucleotides. A lethal ftsZ mutation, ftsZ3 (Rsa), that leads to an amino acid alteration in this homologous segment decreased GTP binding and hydrolysis, suggesting that interaction with GTP is essential for ftsZ function.
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Citations
Cites
The GTPase superfamily: conserved structure and molecular mechanism
Bourne, H. R., Sanders, D. A., & McCormick, F. (1991) · Nature · doi:10.1038/349117a0 · Cited by 3,392
Cited by
Growth of the Stress-Bearing and Shape-Maintaining Murein Sacculus of Escherichia coli
Höltje, J.-V. (1998) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.62.1.181-203.1998 · Cited by 1,129
FtsZ and the division of prokaryotic cells and organelles
Margolin, W. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1745 · Cited by 631
Cabeen, M. T., & Jacobs-Wagner, C. (2005) · Nature Reviews Microbiology · doi:10.1038/nrmicro1205 · Cited by 494
Erickson, H. P., Taylor, D. W., Taylor, K. A., & Bramhill, D. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.1.519 · Cited by 459
Ma, X., Ehrhardt, D. W., & Margolin, W. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.23.12998 · Cited by 444
Metadata
- Authors
- Mukherjee, A., Dai, K., & Lutkenhaus, J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1993-02
- Volume
- 90
- Issue
- 3
- Pages
- 1053-1057
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1977912508
- Cited by
- 312
- References
- 1
- FWCI
- 10.92
- Type
- journal article
- Language
- en
- Open access
- green
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- Mukherjee, A., Dai, K., & Lutkenhaus, J. (1993). Escherichia coli cell division protein FtsZ is a guanine nucleotide binding protein. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.90.3.1053
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