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cDNA cloning of a human mRNA preferentially expressed in hematopoietic cells and with homology to a GDP-dissociation inhibitor for the rho GTP-binding proteins.
Abstract
We have identified the mRNA for a human gene, denoted D4, which is expressed at very high levels in hematopoietic cell lines and in normal cells of lymphoid and myeloid origin. The 1.5-kb transcript is absent or detectable only at low levels in nonhematopoietic tissues. D4 encodes a 201-amino acid protein with homology to rhoGDI, an inhibitor of GDP dissociation for the ras-homologous protein rho. D4 might function also as a regulator of guanine nucleotide exchange for small GTP-binding proteins. A homologous transcript of similar size is also preferentially expressed in murine hematopoietic tissues. When totipotent murine embryonic stem cells develop in vitro into hematopoietic cells, the gene is activated with the onset of hematopoiesis. When hematopoietic cell lines are induced to differentiate, the expression of D4 is modulated. Thus, D4 appears to be a developmentally regulated gene. Its preferential expression in hematopoietic cells indicates that D4 likely plays some significant role in the growth and differentiation processes of hematopoietic cells. This significance is underscored by increasing evidence for the involvement of regulators of G proteins in clinical diseases.
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“Athird regulatory protein that is involved in GTPase activity is the GDI (2, 32, 59).”
From The Hematopoiesis-Specific GTP-Binding Protein RhoH Is GTPase Deficient and Modulates Activities of Other Rho GTPases by an Inhibitory Function (2002) · cites this paper as [32]
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“In vitro assays have shown that GDIs inhibit GDPdissociation and compete with GEF for activation of Rho GTPases (2, 32).”
From The Hematopoiesis-Specific GTP-Binding Protein RhoH Is GTPase Deficient and Modulates Activities of Other Rho GTPases by an Inhibitory Function (2002) · cites this paper as [32]
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Cites
The neurofibromatosis type 1 gene encodes a protein related to GAP
Xu, G., O'Connell, P., Viskochil, D., Cawthon, R., Robertson, M., Culver, M., Dunn, D., Stevens, J., Gesteland, R., White, R., et al. (1990) · Cell · doi:10.1016/0092-8674(90)90024-9 · Cited by 1,095
Research works printed but not linked: 5
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Cited by
Li, X., Bu, X., Lu, B., Avraham, H., Flavell, R. A., & Lim, B. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.4.1158-1171.2002 · Cited by 153
Self-citationRhoH/TTF Negatively Regulates Leukotriene Production in Neutrophils
Daryadel, A., Yousefi, S., Troi, D., Schmid, I., Schmidt-Mende, J., Mordasini, C., Dahinden, C. A., Ziemiecki, A., & Simon, H.-U. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803846 · Cited by 20
Metadata
- Authors
- Lelias, J. M., Adra, C. N., Wulf, G. M., Guillemot, J. C., Khagad, M., Caput, D., & Lim, B.
- Affiliations
- Department of Medicine, Beth Israel Hospital, Harvard Medical School, Boston, MA 02215.
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1993-02-15
- Volume
- 90
- Issue
- 4
- Pages
- 1479-1483
- ISSN
- 0027-8424
- 1091-6490
- Cited by
- 109
- References
- 1
- Language
- en
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