The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Phosphorylation at threonine-235 by a ras-dependent mitogen-activated protein kinase cascade is essential for transcription factor NF-IL6.
Open accessAbstract
NF-IL6, a member of the basic leucine zipper (bZIP) family transcription factors, is involved in expression of inducible genes involved in immune and inflammatory responses. We observed that coexpression of oncogenic p21ras stimulated the transactivating activity of NF-IL6 and induced phosphorylation of Thr-235 located just N-terminal to the DNA binding domain of NF-IL6. Recently, mitogen-activated protein (MAP) kinases have been shown to be implicated in the cellular response to activated ras. Purified MAP kinases specifically phosphorylated Thr-235 of NF-IL6 in vitro. Mutation of Thr-235 abolished the ras-dependent activation of NF-IL6. From these results, we conclude that NF-IL6 is regulated through phosphorylation by MAP kinases in response to activated ras.
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Cites
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Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130
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Self-citationSmeal, T., Binetruy, B., Mercola, D. A., Birrer, M., & Karin, M. (1991) · Nature · doi:10.1038/354494a0 · Cited by 789
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Cited by
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Self-citationInterleukin (IL)-6 directs the differentiation of IL-4-producing CD4+ T cells
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Biological Role of the CCAAT/Enhancer-binding Protein Family of Transcription Factors
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Metadata
- Authors
- Nakajima, T., Kinoshita, S., Sasagawa, T., Sasaki, K., Naruto, M., Kishimoto, T., & Akira, S.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1993-03-15
- Volume
- 90
- Issue
- 6
- Pages
- 2207-2211
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1964842789
- Cited by
- 578
- References
- 5
- FWCI
- 14.11
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Phosphorylation at threonine-235 by a ras-dependent mitogen-activated protein kinase cascade is essential for transcription factor NF-IL6. https://app.cochat.ai/papers/10.1073/pnas.90.6.2207
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- Nakajima, T., Kinoshita, S., Sasagawa, T., Sasaki, K., Naruto, M., Kishimoto, T., & Akira, S. (1993). Phosphorylation at threonine-235 by a ras-dependent mitogen-activated protein kinase cascade is essential for transcription factor NF-IL6. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.90.6.2207
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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