The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Two distinct gene subfamilies within the family of cysteine protease genes.
Open accessAbstract
A cDNA clone for a physiologically regulated Tetrahymena cysteine protease gene was sequenced. The nucleotide sequence predicts that the clone encodes a 336-amino acid protein composed of a 19-residue N-terminal signal sequence followed by a 107-residue propeptide and a 210-residue mature protein. Comparison of the deduced amino acid sequence of the protein with those of other cysteine proteases revealed a highly conserved interspersed amino acid motif in the propeptide region of the protein, the ERFNIN motif. The motif was present in all of the cysteine proteases in the data base with the exception of the cathepsin B-like proteins, which have shorter propeptides. Differences in the propeptides and in conserved amino acids of the mature proteins suggest that the ERFNIN proteases and the cathepsin B-like proteases constitute two distinct subfamilies within the cysteine proteases.
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Improved tools for biological sequence comparison.
Pearson, W. R., & Lipman, D. J. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.8.2444 · Cited by 11,227
Cited by
Cysteine cathepsins: From structure, function and regulation to new frontiers
Turk, V., Stoka, V., Vasiljeva, O., Renko, M., Sun, T., Turk, B., & Turk, D. (2012) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2011.10.002 · Cited by 1,377
Structure of human procathepsin L reveals the molecular basis of inhibition by the prosegment.
Coulombe, R., Grochulski, P., Sivaraman, J., Ménard, R., Mort, J. S., & Cygler, M. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00934.x · Cited by 388
Origin and Early Diversification of the Papain Family of Cysteine Peptidases
Kordiš, D., & Turk, V. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241411761 · Cited by 8
Metadata
- Authors
- Karrer, K. M., Peiffer, S. L., & DiTomas, M. E.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1993-04
- Volume
- 90
- Issue
- 7
- Pages
- 3063-3067
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2041923914
- Cited by
- 357
- References
- 1
- FWCI
- 4.75
- Type
- journal article
- Language
- en
- Open access
- green
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- Karrer, K. M., Peiffer, S. L., & DiTomas, M. E. (1993). Two distinct gene subfamilies within the family of cysteine protease genes. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.90.7.3063
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