The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Specific association between the human DNA repair proteins XPA and ERCC1.
Open accessAbstract
Processing of DNA damage by the nucleotide-excision repair pathway in eukaryotic cells is most likely accomplished by multiprotein complexes. However, the nature of these complexes and the details of the molecular interactions between DNA repair factors are for the most part unknown. Here, we demonstrate both in vivo, using the two-hybrid system, and in vitro, using recombinant proteins, that the human repair factors XPA and ERCC1 specifically interact. In addition, we report an initial determination of the domains in ERCC1 and XPA that mediate this interaction. These results suggest that XPA may play a role in the localization or loading of an incision complex, composed of ERCC1 and possibly other repair factors, onto a damaged site.
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Citations
Cites
Preferential binding of the xeroderma pigmentosum group A complementing protein to damaged DNA
Jones, C. J., & Wood, R. D. (1993) · Biochemistry · doi:10.1021/bi00096a021 · Cited by 291
Cited by
Flexible nets: The roles of intrinsic disorder in protein interaction networks
Dunker, A. K., Cortese, M. S., Romero, P., Iakoucheva, L. M., & Uversky, V. N. (2005) · The FEBS Journal · doi:10.1111/j.1742-4658.2005.04948.x · Cited by 1,122
Molecular mechanism of nucleotide excision repair
de Laat, W. L., Jaspers, N. G. J., & Hoeijmakers, J. H. J. (1999) · Genes & Development · doi:10.1101/gad.13.7.768 · Cited by 1,122
Takekawa, M., & Saito, H. (1998) · Cell · doi:10.1016/s0092-8674(00)81619-0 · Cited by 746
Nucleotide excision repair and human syndromes
de Boer, J., & Hoeijmakers, J. H. J. (2000) · Carcinogenesis · doi:10.1093/carcin/21.3.453 · Cited by 674
Molecular Mechanisms of Mammalian Global Genome Nucleotide Excision Repair
Gillet, L. C. J., & Schärer, O. D. (2006) · Chemical Reviews · doi:10.1021/cr040483f · Cited by 642
Metadata
- Authors
- Li, L., Elledge, S. J., Peterson, C. A., Bales, E. S., & Legerski, R. J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1994-05-24
- Volume
- 91
- Issue
- 11
- Pages
- 5012-5016
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1992431849
- Cited by
- 304
- References
- 1
- FWCI
- 8.21
- Type
- journal article
- Language
- en
- Open access
- green
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- Li, L., Elledge, S. J., Peterson, C. A., Bales, E. S., & Legerski, R. J. (1994). Specific association between the human DNA repair proteins XPA and ERCC1. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.91.11.5012
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
