The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Central effects of baroreceptor activation in humans: attenuation of skeletal reflexes and pain perception.
Open accessAbstract
Activating the arterial baroreceptors blunts pain sensation and produces other forms of central nervous system inhibition in animals. These effects may be important to blood pressure regulation but have not been rigorously verified in humans. We describe (i) a noninvasive behaviorally unbiased method for baroreceptor stimulation and (ii) the application of this method to measurement of baroreceptor-mediated attenuation of pain perception and of the Achilles tendon reflex. The findings are relevant to basic mechanisms of blood pressure stabilization and cardiovascular reactivity and may also have implications for noncompliance with antihypertensive medications and for the pathophysiology of essential hypertension.
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“In humans, artificially boosting baroreceptor activation reduces pain sensation 53 .”
From Interoceptive rhythms in the brain (2023) · cites this paper as [53]
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Cites
Endogenous Pain Control Systems: Brainstem Spinal Pathways and Endorphin Circuitry
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Pickering, T. G. (1982) · JAMA · doi:10.1001/jama.247.7.992 · Cited by 522
Human Baroreflexes in Health and Disease
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Tonus sympathique et activité électrique corticale
Bonvallet, M., Dell, P., & Hiebel, G. (1954) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(54)90011-5 · Cited by 418
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Baroreceptor Activation Reduces Reactivity to Noxious Stimulation: Implications for Hypertension
Dworkin, B. R., Filewich, R. J., Miller, N. E., Craigmyle, N., & Pickering, T. G. (1979) · Science · doi:10.1126/science.472749 · Cited by 317
Self-citationA simplified neck suction device for activation of carotid baroreceptors.
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The intracutaneous stimulus: a new pain model for algesimetric studies.
Bromm, B., & Meier, W. (1984) · PubMed · Cited by 220
Temporal response patterns of the human sinus node to brief carotid baroreceptor stimuli.
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Research works printed but not linked: 1
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Kosek, E., & Hansson, P. T. (1997) · Pain · doi:10.1016/s0304-3959(96)03295-2 · Cited by 539
Kosek, E., & Ordeberg, G. (2000) · Pain · doi:10.1016/s0304-3959(00)00310-9 · Cited by 476
Visceral Signals Shape Brain Dynamics and Cognition
Azzalini, D., Rebollo, I., & Tallon-Baudry, C. (2019) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2019.03.007 · Cited by 409
Bruehl, S. P., & Chung, O. Y. (2004) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2004.06.004 · Cited by 377
Gianaros, P. J., van der Veen, F. M., & Jennings, J. R. (2004) · Psychophysiology · doi:10.1111/1469-8986.2004.00179.x · Cited by 327
Metadata
- Authors
- Dworkin, B. R., Elbert, T., Rau, H., Birbaumer, N., Pauli, P., Droste, C., & Brunia, C. H.
- Affiliations
- Pennsylvania State University (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1994-07-05
- Volume
- 91
- Issue
- 14
- Pages
- 6329-6333
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC44195
- OpenAlex
- W2119445707
- Cited by
- 251
- References
- 27
- Citations by year
- 2026: 8 · 2025: 7 · 2024: 12 · 2023: 12 · 2022: 11 · 2021: 7 · 2020: 5 · 2019: 8 · 2018: 8 · 2017: 8 · 2016: 9 · 2015: 8 · 2014: 9 · 2013: 15 · 2012: 8
- FWCI
- 6.32
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Research portal (Tilburg University) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- KOPS (University of Konstanz) (submittedVersion, cc-by-nc-nd)
- Funders
- National Heart, Lung, and Blood Institute (R01 HL40837, R01HL040837)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Syncope and Autonomic Disorders
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Keywords
- baroreceptor activation, pain perception, Achilles tendon reflex, central nervous system inhibition, blood pressure regulation, cardiovascular reactivity, essential hypertension
- MeSH terms
- Achilles Tendon, Adult, Analysis of Variance, Blood Pressure, Carotid Arteries, Central Nervous System, Electric Stimulation, Humans, Hypertension, Middle Aged, Muscle, Smooth, Vascular, Pain, Pressoreceptors, Reflex, Sensory Thresholds, Myocardial Ischemia
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