The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Two highly homologous members of the ClC chloride channel family in both rat and human kidney.
Open accessAbstract
We have cloned two closely related putative Cl- channels from both rat kidney (designated rClC-K1 and rClC-K2) and human kidney (hClC-Ka and hClC-Kb) by sequence homology to the ClC family of voltage-gated Cl- channels. While rClC-K1 is nearly identical to ClC-K1, a channel recently isolated by a similar strategy, rClC-K2 is 80% identical to rClC-K1 and is encoded by a different gene. hClC-Ka and hClC-Kb show approximately 90% identity, while being approximately 80% identical to the rat proteins. All ClC-K gene products are expressed predominantly in the kidney. While rClC-K1 is expressed strongly in the cortical thick ascending limb and the distal convoluted tubule, with minor expression in the S3 segment of the proximal tubule and the cortical collecting tubule, rClC-K2 is expressed in all segments of the nephron examined, including the glomerulus. Since they are related more closely to each other than to the rat proteins, hClC-Ka and hClC-Kb cannot be regarded as strict homologs of rClC-K1 or rClC-K2. After injection of ClC-K cRNAs into oocytes, corresponding proteins were made and glycosylated, though no additional Cl- currents were detectable. Glycosylation occurs between domains D8 and D9, leading to a revision of the transmembrane topology model for ClC channels.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Identification of the Cystic Fibrosis Gene: Cloning and Characterization of Complementary DNA
Riordan, J. R., Rommens, J. M., Kerem, B.-S., Alon, N., Rozmahel, R., Grzelczak, Z., Zielenski, J., Lok, S., Plavsic, N., Chou, J.-L., et al. (1989) · Science · doi:10.1126/science.2475911 · Cited by 7,418
Cited by
Molecular Structure and Physiological Function of Chloride Channels
Jentsch, T. J., Stein, V., Weinreich, F., & Zdebik, A. A. (2002) · Physiological Reviews · doi:10.1152/physrev.00029.2001 · Cited by 1,256
Self-citationMutations in the Chloride Channel Gene CLCNKB as a Cause of Classic Bartter Syndrome
KONRAD, M., VOLLMER, M., LEMMINK, H. H., VAN DEN HEUVEL, L. P. W. J., JECK, N., VARGAS-POUSSOU, R., LAKINGS, A., RUF, R., DESCHE[Combining Circumflex Accent]NES, G., ANTIGNAC, C., et al. (2000) · Journal of the American Society of Nephrology · doi:10.1681/asn.v1181449 · Cited by 289
Structure of a CLC chloride ion channel by cryo-electron microscopy
Park, E., Campbell, E. B., & MacKinnon, R. (2017) · Nature · doi:10.1038/nature20812 · Cited by 164
Inherited Disorders of Renal Salt Homeostasis
Scholl, U. I., & Lifton, R. P. (2013) · Seldin and Giebisch's The Kidney · doi:10.1016/b978-0-12-381462-3.00036-7 · Cited by 10
A large‐scale evolutionary and structural analysis of CLC channels and transporters
Mishra, A., Díaz Vázquez, G., & Robertson, J. L. (2025) · Protein Science · doi:10.1002/pro.70389 · Cited by 3
“Channel homologs include CLC-0 (Lísal & Maduke, 2008), hCLC-Ka/b (Kieferle et al., 1994), hCLC-1 (Saviane et al., 1999), hCLC-2 (Britton et al., 2005), and a putative channel ngCLC (Fortea Verdejo, 2021); transporter homologs include hCLC-3 (Guzman et al., 2013), hCLC-4, hCLC-5 (Picollo & Pusch,…”
Metadata
- Authors
- Kieferle, S., Fong, P., Bens, M., Vandewalle, A., & Jentsch, T. J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1994-07-19
- Volume
- 91
- Issue
- 15
- Pages
- 6943-6947
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2016872644
- Cited by
- 285
- References
- 1
- FWCI
- 5.39
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Two highly homologous members of the ClC chloride channel family in both rat and human kidney. https://app.cochat.ai/papers/10.1073/pnas.91.15.6943
- The paper
- Kieferle, S., Fong, P., Bens, M., Vandewalle, A., & Jentsch, T. J. (1994). Two highly homologous members of the ClC chloride channel family in both rat and human kidney. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.91.15.6943
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
