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Promotion of parallel DNA quadruplexes by a yeast telomere binding protein: a circular dichroism study.
Open accessAbstract
Repressor-activator protein 1 (RAP1) has an essential role in the maintenance of yeast telomeres. Yeast telomeric DNA consists of simple repeated G-rich sequences that are bound by RAP1. We have found that RAP1, in addition to its known binding activity for double-stranded DNA, interacts with the G-rich strand containing guanine base (G)-tetrads. We show here using circular dichroism spectroscopy that RAP1 promotes the formation of one particular type of DNA quadruplex, parallel G4-DNA. Furthermore, RAP1 is able to bind to both preformed parallel and antiparallel DNA quadruplexes. These results have implications for the possible use of DNA quadruplexes in telomere-telomere association in vivo.
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Cited by
Teixeira, M. T., Arneric, M., Sperisen, P., & Lingner, J. (2004) · Cell · doi:10.1016/s0092-8674(04)00334-4 · Cited by 526
Loop-Length-Dependent Folding of G-Quadruplexes
Hazel, P., Huppert, J., Balasubramanian, S., & Neidle, S. (2004) · Journal of the American Chemical Society · doi:10.1021/ja045154j · Cited by 494
Chemistry in human telomere biology: structure, function and targeting of telomere DNA/RNA
Xu, Y. (2011) · Chemical Society Reviews · doi:10.1039/c0cs00134a · Cited by 323
Metadata
- Authors
- Giraldo, R., Suzuki, M., Chapman, L., & Rhodes, D.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1994-08-02
- Volume
- 91
- Issue
- 16
- Pages
- 7658-7662
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2052445290
- Cited by
- 214
- References
- 0
- FWCI
- 2.57
- Type
- journal article
- Language
- en
- Open access
- green
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- Giraldo, R., Suzuki, M., Chapman, L., & Rhodes, D. (1994). Promotion of parallel DNA quadruplexes by a yeast telomere binding protein: a circular dichroism study. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.91.16.7658
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