The DOI matches its Crossref record.
An integral membrane protein (LMP2) blocks reactivation of Epstein-Barr virus from latency following surface immunoglobulin crosslinking.
Open accessAbstract
The role of latent membrane protein 2 (LMP2) in Epstein-Barr virus (EBV) infection was evaluated by using latently infected primary B lymphocytes that had been growth transformed by wild-type or specifically mutated EBV recombinants. LMP2 null mutant recombinant EBV-infected cells were similar to normal B lymphocytes in their rapid increase in intracellular free calcium after surface immunoglobulin crosslinking. These cells also became more permissive for lytic EBV replication. In sharp contrast, wild-type control infected cells had little or no increase in intracellular free calcium or in permissivity for EBV replication. The block to surface immunoglobulin crosslinking-induced permissivity in cells expressing wild-type LMP2 could be bypassed by raising intracellular free calcium levels with an ionophore and by activating protein kinase C with phorbol 12-myristate 13-acetate. LMP2A, not LMP2B, mediates this effect on calcium mobilization. Genetic and biochemical data are consistent with these effects being due to the interaction of the LMP2A N-terminal cytoplasmic domain with B lymphocyte src family tyrosine kinases.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
The Nedd4 family of E3 ubiquitin ligases: functional diversity within a common modular architecture
Ingham, R. J., Gish, G., & Pawson, T. (2004) · Oncogene · doi:10.1038/sj.onc.1207436 · Cited by 531
Epstein–Barr virus latent genes
Kang, M.-S., & Kieff, E. (2015) · Experimental & Molecular Medicine · doi:10.1038/emm.2014.84 · Cited by 361
Self-citationDawson, C. W., Port, R. J., & Young, L. S. (2012) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2012.01.004 · Cited by 355
Epstein-Barr virus—recent advances
Macsween, K. F., & Crawford, D. H. (2003) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(03)00543-7 · Cited by 344
Infectious agents and cancer: criteria for a causal relation
Pagano, J. S., Blaser, M., Buendia, M.-A., Damania, B., Khalili, K., Raab-Traub, N., & Roizman, B. (2004) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2004.06.009 · Cited by 337
Metadata
- Authors
- Miller, C. L., Lee, J. H., Kieff, E., & Longnecker, R.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1994-01-18
- Volume
- 91
- Issue
- 2
- Pages
- 772-776
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2063227295
- Cited by
- 257
- References
- 0
- FWCI
- 4.50
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: An integral membrane protein (LMP2) blocks reactivation of Epstein-Barr virus from latency following surface immunoglobulin crosslinking. https://app.cochat.ai/papers/10.1073/pnas.91.2.772
- The paper
- Miller, C. L., Lee, J. H., Kieff, E., & Longnecker, R. (1994). An integral membrane protein (LMP2) blocks reactivation of Epstein-Barr virus from latency following surface immunoglobulin crosslinking. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.91.2.772
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
