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High-affinity reactions between antigen-specific T-cell receptors and peptides associated with allogeneic and syngeneic major histocompatibility complex class I proteins.
Open accessAbstract
We report here that the intrinsic affinities of the antigen-specific T-cell receptors (TCR) of two unrelated CD8+ T-cell clones for their respective peptide-major histocompatibility complex (MHC) ligands are higher than the values generally thought to prevail for TCR. The TCR of one clone (2C) binds an allogeneic class I MHC protein (Ld) in association with an alpha-ketoglutarate dehydrogenase nonapeptide (QLSPFPFDL, termed QL9) with an intrinsic affinity (intrinsic equilibrium association constant) of 1-2 x 10(7) M-1. The TCR of the other clone (4G3) binds a syngeneic class I MHC protein (Kb) in association with an ovalbumin octapeptide (SIINFEKL, termed pOV8) with an intrinsic affinity of 1.5 x 10(6) M-1. A comparison of the two clones, combined with current views of T-cell repertoire selection in the thymus, leads us to propose that TCR affinities are generally likely to be higher for allogeneic MHC-peptide complexes than for syngeneic MHC-peptide complexes.
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Citations
Cited by
Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion
Dong, H., Strome, S. E., Salomao, D. R., Tamura, H., Hirano, F., Flies, D. B., Roche, P. C., Lu, J., Zhu, G., Tamada, K., et al. (2002) · Nature Medicine · doi:10.1038/nm730 · Cited by 5,025
CD8 enhances formation of stable T-cell receptor/MHC class I molecule complexes
Garcia, K. C., Scott, C. A., Brunmark, A., Carbone, F. R., Peterson, P. A., Wilson, I. A., & Teyton, L. (1996) · Nature · doi:10.1038/384577a0 · Cited by 323
Self-citationIn vitro evolution of a T cell receptor with high affinity for peptide/MHC
Holler, P. D., Holman, P. O., Shusta, E. V., O'Herrin, S., Wittrup, K. D., & Kranz, D. M. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.080078297 · Cited by 295
B7-H1 pathway and its role in the evasion of tumor immunity
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Metadata
- Authors
- Sykulev, Y., Brunmark, A., Tsomides, T. J., Kageyama, S., Jackson, M., Peterson, P. A., & Eisen, H. N.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1994-11-22
- Volume
- 91
- Issue
- 24
- Pages
- 11487-11491
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2047747639
- Cited by
- 194
- References
- 0
- FWCI
- 6.88
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: High-affinity reactions between antigen-specific T-cell receptors and peptides associated with allogeneic and syngeneic major histocompatibility complex class I proteins. https://app.cochat.ai/papers/10.1073/pnas.91.24.11487
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- Sykulev, Y., Brunmark, A., Tsomides, T. J., Kageyama, S., Jackson, M., Peterson, P. A., & Eisen, H. N. (1994). High-affinity reactions between antigen-specific T-cell receptors and peptides associated with allogeneic and syngeneic major histocompatibility complex class I proteins. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.91.24.11487
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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