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The Gal(alpha 1-4)Gal-specific tip adhesin of Escherichia coli P-fimbriae is needed for pyelonephritis to occur in the normal urinary tract.
Open accessAbstract
Nonobstructive acute pyelonephritis in humans is most often caused by P-fimbriated Escherichia coli. P-fimbriae are heteropolymeric fibers carrying a Gal(alpha 1-4)Gal-specific PapG adhesin at its distal end. The pyelonephritic strain DS17 expresses P-fimbriae from a single gene cluster. A mutant strain, DS17-8, which expresses P-fimbriae tacking the PapG adhesin, was constructed by allelic replacement introducing a 1-bp deletion early in the papG gene. In cynomolgus monkeys, DS17 and DS17-8 were equally able to cause bladder infection, whereas only the wild-type strain DS17 could cause pyelonephritis as monitored by bacteriological, functional, and histopathological criteria. Since DS17, but not DS17-8, adheres to renal tissue, these data underscore the critical role of microbial adherence to host tissues in infectious disease and strongly suggest that the PapG tip adhesin of P-fimbriae is essential in the pathogenesis of human kidney infection.
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Citations
Cited by
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Karlsson, K.-A. (1995) · Current Opinion in Structural Biology · doi:10.1016/0959-440x(95)80054-9 · Cited by 310
Jones, C. H. (1997) · The EMBO Journal · doi:10.1093/emboj/16.21.6394 · Cited by 299
Multiple pathways allow protein secretion across the bacterial outer membrane
Thanassi, D. G., & Hultgren, S. J. (2000) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(00)00111-3 · Cited by 294
Ulett, G. C., Valle, J., Beloin, C., Sherlock, O., Ghigo, J.-M., & Schembri, M. A. (2007) · Infection and Immunity · doi:10.1128/iai.01952-06 · Cited by 214
Bäckhed, F., Alsén, B., Roche, N., Ångström, J., von Euler, A., Breimer, M. E., Westerlund-Wikström, B., Teneberg, S., & Richter-Dahlfors, A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111640200 · Cited by 96
Metadata
- Authors
- Roberts, J. A., Marklund, B. I., Ilver, D., Haslam, D., Kaack, M. B., Baskin, G., Louis, M., Möllby, R., Winberg, J., & Normark, S.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1994-12-06
- Volume
- 91
- Issue
- 25
- Pages
- 11889-11893
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2109359144
- Cited by
- 364
- References
- 0
- FWCI
- 8.32
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: The Gal(alpha 1-4)Gal-specific tip adhesin of Escherichia coli P-fimbriae is needed for pyelonephritis to occur in the normal urinary tract. https://app.cochat.ai/papers/10.1073/pnas.91.25.11889
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- Roberts, J. A., Marklund, B. I., Ilver, D., Haslam, D., Kaack, M. B., Baskin, G., Louis, M., Möllby, R., Winberg, J., & Normark, S. (1994). The Gal(alpha 1-4)Gal-specific tip adhesin of Escherichia coli P-fimbriae is needed for pyelonephritis to occur in the normal urinary tract. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.91.25.11889
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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