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Distinct isoforms of neuregulin are expressed in mesenchymal and neuronal cells during mouse development.
Open accessAbstract
Neuregulin, the putative ligand of the c-neu receptor tyrosine kinase, can induce differentiation or growth of epithelia and other cells. To gain insight into the biological role of this factor, we have analyzed the expression of neuregulin during mouse embryogenesis and in the perinatal animal by a combination of in situ hybridization and RNase protection experiments. We identify sites of expression that correspond to mesenchymal cells of various parenchymal organs. Our finding implies a function of neuregulin as a mesenchymal factor that acts on epithelia. The mesenchymal expression of neuregulin could thus provide a molecular basis for the biological phenomenon of mesenchymal-epithelial interactions. It also has implications on the molecular mechanism by which amplification of c-neu can affect tumor progression of carcinomas. In addition, neuregulin expression is found in neuronal cells during development. We show by RNase protection experiments that distinct isoforms of neuregulin are expressed in the brain. Therefore, our data indicate in vivo a dual role for neuregulin as mesenchymal and neuronal factor.
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Peles, E., Bacus, S. S., Koski, R. A., Lu, H. S., Wen, D., Ogden, S. G., Levy, R. B., & Yarden, Y. (1992) · Cell · doi:10.1016/0092-8674(92)90131-u · Cited by 524
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Yang, Y., Spitzer, E., Meyer, D., Sachs, M., Niemann, C., Hartmann, G., Weidner, K. M., Birchmeier, C., & Birchmeier, W. (1995) · The Journal of cell biology · doi:10.1083/jcb.131.1.215 · Cited by 300
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Metadata
- Authors
- Meyer, D., & Birchmeier, C.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1994-02
- Volume
- 91
- Issue
- 3
- Pages
- 1064-1068
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2084602457
- Cited by
- 176
- References
- 1
- FWCI
- 7.23
- Type
- journal article
- Language
- en
- Open access
- green
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- Meyer, D., & Birchmeier, C. (1994). Distinct isoforms of neuregulin are expressed in mesenchymal and neuronal cells during mouse development. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.91.3.1064
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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