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Overexpression of parathyroid hormone-related protein in the skin of transgenic mice interferes with hair follicle development.
Open accessAbstract
Parathyroid hormone-related peptide (PTHrP) was initially discovered as the cause of the syndrome of humoral hypercalcemia of malignancy. Subsequently, the PTHrP gene has been shown to be expressed in a wide variety of normal tissues, including skin. Because the biological function of PTHrP in skin remains unknown, we used the human keratin 14 promoter to target overexpression of PTHrP to the skin of transgenic mice. We achieved a 10-fold level of overexpression in skin, and human keratin 14 promoter-PTHrP transgenic mice displayed a disturbance in normal hair follicle development. These mice either failed to initiate follicle development or showed a delay in the initiation of follicles. These findings suggest that PTHrP normally plays a role in the early stages of hair follicle development and support previous speculation that the peptide may function in regulating cellular differentiation.
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Citations
Cited by
Controls of Hair Follicle Cycling
Stenn, K. S., & Paus, R. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.1.449 · Cited by 1,519
Neuroendocrinology of the Skin1
Slominski, A., & Wortsman, J. (2000) · Endocrine Reviews · doi:10.1210/edrv.21.5.0410 · Cited by 727
Amizuka, N., Warshawsky, H., Henderson, J. E., Goltzman, D., & Karaplis, A. C. (1994) · The Journal of cell biology · doi:10.1083/jcb.126.6.1611 · Cited by 454
Role of Hormones in Pilosebaceous Unit Development
Deplewski, D., & Rosenfield, R. L. (2000) · Endocrine Reviews · doi:10.1210/edrv.21.4.0404 · Cited by 443
Lee, K. (1995) · Endocrinology · doi:10.1210/en.136.2.453 · Cited by 371
Metadata
- Authors
- Wysolmerski, J. J., Broadus, A. E., Zhou, J., Fuchs, E., Milstone, L. M., & Philbrick, W. M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1994-02
- Volume
- 91
- Issue
- 3
- Pages
- 1133-1137
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2009900140
- Cited by
- 206
- References
- 0
- FWCI
- 20.92
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Overexpression of parathyroid hormone-related protein in the skin of transgenic mice interferes with hair follicle development. https://app.cochat.ai/papers/10.1073/pnas.91.3.1133
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- Wysolmerski, J. J., Broadus, A. E., Zhou, J., Fuchs, E., Milstone, L. M., & Philbrick, W. M. (1994). Overexpression of parathyroid hormone-related protein in the skin of transgenic mice interferes with hair follicle development. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.91.3.1133
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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