The DOI matches its Crossref record.
A human amphotropic retrovirus receptor is a second member of the gibbon ape leukemia virus receptor family.
Open accessAbstract
Retrovirus infection is initiated by binding of the viral envelope glycoprotein to a cell-surface receptor. The envelope proteins of type C retroviruses of mammals demonstrate similarities in structural organization and protein sequence. These similarities suggest the possibility that retroviruses from different interference groups might use related proteins as receptors, despite the absence of any relationship between retrovirus receptors isolated to date. To investigate this possibility, we have identified a human cDNA clone encoding a protein closely related to the receptor for gibbon ape leukemia virus and have found that it functions as the receptor for the amphotropic group of murine retroviruses. Expression of this protein (GLVR-2) is likely to be a requirement for infection of human cells by amphotropic retroviral vectors for purposes of gene therapy.
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Cited by
Kavanaugh, M. P., Miller, D. G., Zhang, W., Law, W., Kozak, S. L., Kabat, D., & Miller, A. D. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.15.7071 · Cited by 586
Progress in the Use of Gene Transfer Methods to Treat Genetic Blood Diseases
Williams, D. A., & Smith, F. O. (2000) · Human Gene Therapy · doi:10.1089/104303400750001372 · Cited by 32
Metadata
- Authors
- van Zeijl, M., Johann, S. V., Closs, E., Cunningham, J., Eddy, R., Shows, T. B., & O'Hara, B.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1994-02
- Volume
- 91
- Issue
- 3
- Pages
- 1168-1172
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2068414038
- Cited by
- 256
- References
- 0
- FWCI
- 12.86
- Type
- journal article
- Language
- en
- Open access
- green
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- The paper
- van Zeijl, M., Johann, S. V., Closs, E., Cunningham, J., Eddy, R., Shows, T. B., & O'Hara, B. (1994). A human amphotropic retrovirus receptor is a second member of the gibbon ape leukemia virus receptor family. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.91.3.1168
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
