The DOI matches its Crossref record.
Combinatorially selected guanosine-quartet structureis a potent inhibitor of human immunodeficiency virus envelope-mediated cellfusion.
Open accessAbstract
The phosphorothioate oligonucleotide T2G4T2 was identified as an inhibitor of HIV infection in vitro by combinatorial screening of a library of phosphorothioate oligonucleotides that contained all possible octanucleotide sequences. The oligonucleotide forms a parallel-stranded tetrameric guanosine-quartet structure. Tetramer formation and the phosphorothioate backbone are essential for antiviral activity. The tetramer binds to the human immunodeficiency virus envelope protein gp120 at the V3 loop and inhibits both cell-to-cell and virus-to-cell infection.
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Citations
Cited by
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Metadata
- Authors
- Wyatt, J. R., Vickers, T. A., Roberson, J. L., Buckheit, R. W., Klimkait, T., DeBaets, E., Davis, P. W., Rayner, B., Imbach, J. L., & Ecker, D. J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1994-02-15
- Volume
- 91
- Issue
- 4
- Pages
- 1356-1360
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2107634357
- Cited by
- 300
- References
- 0
- FWCI
- 11.15
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Combinatorially selected guanosine-quartet structureis a potent inhibitor of human immunodeficiency virus envelope-mediated cellfusion. https://app.cochat.ai/papers/10.1073/pnas.91.4.1356
- The paper
- Wyatt, J. R., Vickers, T. A., Roberson, J. L., Buckheit, R. W., Klimkait, T., DeBaets, E., Davis, P. W., Rayner, B., Imbach, J. L., & Ecker, D. J. (1994). Combinatorially selected guanosine-quartet structureis a potent inhibitor of human immunodeficiency virus envelope-mediated cellfusion. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.91.4.1356
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
