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Secretion of human hepatitis B virus is inhibited by the imino sugar N-butyldeoxynojirimycin.
Open accessAbstract
The imino sugar N-butyldeoxynojirimycin (NBDNJ) is a potent inhibitor of the oligosaccharide-trimming enzyme alpha-glucosidase I. Hepatitis B virus (HBV) contains three surface proteins (HBs proteins) of different sizes that are singly or doubly N-glycosylated and are essential for the formation of infectious virus. Therefore, the replication and secretion of HBV in the human hepatoma cell line HepG2 were studied in the presence of NBDNJ. In the stably HBV-transfected HepG 2.2.15 cells and in HBV-infected HepG2 cells, NBDNJ suppressed secretion of HBV particles and caused intracellular retention of HBV DNA. The secretion of subviral particles was less affected. These data suggest that inhibitors of oligosaccharide trimming may be useful for antiviral therapy of hepatitis B and for the study of the intracellular transport of the viral glycoproteins.
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Citations
Cited by
Asano, N., Nash, R. J., Molyneux, R. J., & Fleet, G. W. J. (2000) · Tetrahedron: Asymmetry · doi:10.1016/s0957-4166(00)00113-0 · Cited by 1,015
Glycosidase inhibitors: update and perspectives on practical use
Asano, N. (2003) · Glycobiology · doi:10.1093/glycob/cwg090 · Cited by 715
α- and β-Glucosidase inhibitors: chemical structure and biological activity
Borges de Melo, E., da Silveira Gomes, A., & Carvalho, I. (2006) · Tetrahedron · doi:10.1016/j.tet.2006.08.055 · Cited by 548
Targeting glycosylation as a therapeutic approach
Dwek, R. A., Butters, T. D., Platt, F. M., & Zitzmann, N. (2002) · Nature Reviews Drug Discovery · doi:10.1038/nrd708 · Cited by 420
Self-citationIminosugars past, present and future: Medicines for tomorrow
Horne, G., Wilson, F. X., Tinsley, J., Williams, D. H., & Storer, R. (2011) · Drug Discovery Today · doi:10.1016/j.drudis.2010.08.017 · Cited by 320
Metadata
- Authors
- Block, T. M., Lu, X., Platt, F. M., Foster, G. R., Gerlich, W. H., Blumberg, B. S., & Dwek, R. A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1994-03-15
- Volume
- 91
- Issue
- 6
- Pages
- 2235-2239
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2082845444
- Cited by
- 186
- References
- 0
- FWCI
- 4.92
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Secretion of human hepatitis B virus is inhibited by the imino sugar N-butyldeoxynojirimycin. https://app.cochat.ai/papers/10.1073/pnas.91.6.2235
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- Block, T. M., Lu, X., Platt, F. M., Foster, G. R., Gerlich, W. H., Blumberg, B. S., & Dwek, R. A. (1994). Secretion of human hepatitis B virus is inhibited by the imino sugar N-butyldeoxynojirimycin. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.91.6.2235
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
