The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Triterpene derivatives that block entry of human immunodeficiency virus type 1 into cells.
Open accessAbstract
A series of triterpene compounds characterized by a stringent structure-activity relationship were identified as potent and selective inhibitors of human immunodeficiency virus type 1 (HIV-1) replication. Currently studied botulinic derivatives have 50% inhibitory concentrations (IC50) against HIV-1 strain IIIB/LAI in the 10 nM range in several cellular infection assays but are inactive against HIV-2. These compounds did not significantly inhibit the in vitro activities of several purified HIV-1 enzymes. Rather, they appeared to block virus infection at a postbinding, envelope-dependent step involved in the fusion of the virus to the cell membrane.
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Citations
Cites
pH-independent HIV entry into CD4-positive T cells via virus envelope fusion to the plasma membrane
Stein, B. S., Gowda, S. D., Lifson, J. D., Penhallow, R. C., Bensch, K. G., & Engleman, E. G. (1987) · Cell · doi:10.1016/0092-8674(87)90542-3 · Cited by 627
Cited by
Pharmacological activities of natural triterpenoids and their therapeutic implications
Dzubak, P., Hajduch, M., Vydra, D., Hustova, A., Kvasnica, M., Biedermann, D., Markova, L., Urban, M., & Sarek, J. (2006) · Natural Product Reports · doi:10.1039/b515312n · Cited by 708
Cichewicz, R. H., & Kouzi, S. A. (2004) · Medicinal Research Reviews · doi:10.1002/med.10053 · Cited by 531
Current lead natural products for the chemotherapy of human immunodeficiency virus (HIV) infection
De Clercq, E. (2000) · Medicinal Research Reviews · doi:10.1002/1098-1128(200009)20:5<323::aid-med1>3.0.co;2-a · Cited by 355
Self-citationBetulinic Acid and Dihydrobetulinic Acid Derivatives as Potent Anti-HIV Agents
Kashiwada, Y., Hashimoto, F., Cosentino, L. M., Chen, C.-H., Garrett, P. E., & Lee, K.-H. (1996) · Journal of Medicinal Chemistry · doi:10.1021/jm950922q · Cited by 272
Metadata
- Authors
- Mayaux, J. F., Bousseau, A., Pauwels, R., Huet, T., Hénin, Y., Dereu, N., Evers, M., Soler, F., Poujade, C., & De Clercq, E.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1994-04-26
- Volume
- 91
- Issue
- 9
- Pages
- 3564-3568
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1977566529
- Cited by
- 172
- References
- 1
- FWCI
- 0.98
- Type
- journal article
- Language
- en
- Open access
- green
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- The paper
- Mayaux, J. F., Bousseau, A., Pauwels, R., Huet, T., Hénin, Y., Dereu, N., Evers, M., Soler, F., Poujade, C., & De Clercq, E. (1994). Triterpene derivatives that block entry of human immunodeficiency virus type 1 into cells. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.91.9.3564
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
