The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Purification and physiological evaluation of a guanylate cyclase activating protein from retinal rods.
Open accessAbstract
In retinal rods light triggers a cascade of enzymatic reactions that increases cGMP hydrolysis and generates an electrical signal by causing closure of cGMP-gated ion channels in the photoreceptor outer segment. This leads to a decrease in internal Ca, which activates guanylate cyclase and promotes photoresponse recovery by stimulating the resynthesis of cGMP. We report here that the activation of guanylate cyclase by low Ca is mediated by an approximately 20-kDa protein purified from bovine rod outer segments by using DEAE-Sepharose, hydroxylapatite, and reverse-phase chromatographies. In a reconstituted system, this protein restores the Ca-sensitive regulation of guanylate cyclase and when dialyzed into functionally intact lizard rod outer segment decreases the sensitivity, time to peak, and recovery time of the flash response.
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Cites
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Highly cooperative feedback control of retinal rod guanylate cyclase by calcium ions
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Recoverin: a Calcium Sensitive Activator of Retinal Rod Guanylate Cyclase
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Cited by
Ebrey, T., & Koutalos, Y. (2001) · Progress in Retinal and Eye Research · doi:10.1016/s1350-9462(00)00014-8 · Cited by 441
Molecular cloning and characterization of retinal photoreceptor guanylyl cyclase-activating protein
Palczewski, K., Subbaraya, I., Gorczyca, W. A., Helekar, B. S., Ruiz, C. C., Ohguro, H., Huang, J., Zhao, X., Crabb, J. W., Johnson, R. S., et al. (1994) · Neuron · doi:10.1016/0896-6273(94)90355-7 · Cited by 371
Self-citationDizhoor, A. (1994) · Neuron · doi:10.1016/0896-6273(94)90449-9 · Cited by 347
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Turned on by Ca2+! The physiology and pathology of Ca2+-binding proteins in the retina
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Metadata
- Authors
- Gorczyca, W. A., Gray-Keller, M. P., Detwiler, P. B., & Palczewski, K.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1994-04-26
- Volume
- 91
- Issue
- 9
- Pages
- 4014-4018
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1989678684
- Cited by
- 253
- References
- 28
- FWCI
- 11.28
- Type
- journal article
- Language
- en
- Open access
- green
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- Gorczyca, W. A., Gray-Keller, M. P., Detwiler, P. B., & Palczewski, K. (1994). Purification and physiological evaluation of a guanylate cyclase activating protein from retinal rods. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.91.9.4014
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
